{"created":"2024-12-12T07:16:56.456059+00:00","id":2009787,"links":{},"metadata":{"_buckets":{"deposit":"280b80ae-29fb-4d3a-bf1b-928907e30d85"},"_deposit":{"created_by":7,"id":"2009787","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009787"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009787","sets":["1713853213384:1713853295607"]},"author_link":["500","1252","365","478","305"],"control_number":"2009787","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"103448","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"iScience","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The eIF2α phosphorylation-dependent integrated stress response (ISR) is a signaling pathway that maintains homeostasis in mammalian cells exposed to various stresses. Here, ISR activation in adipocytes improves obesity and diabetes by regulating appetite in a non-cell-autonomous manner. Adipocyte-specific ISR activation using transgenic mice decreases body weight and improves glucose tolerance and obesity induced by a high-fat diet (HFD) via preferential inhibition of HFD intake. The transcriptome analysis of ISR-activated adipose tissue reveals that growth differentiation factor 15 (GDF15) expression is induced by the ISR through the direct regulation of the transcription factors ATF4 and DDIT3. Deficiency in the GDF15 receptor GFRAL abolishes the adipocyte ISR-dependent preferential inhibition of HFD intake and the anti-obesity effects. Pharmacologically, 10(E), 12(Z)-octadecadienoic acid induces ISR-dependent GDF15 expression in adipocytes and decreases the intake of the HFD. Based on our findings the specific activation of the ISR in adipocytes controls the non-cell-autonomous regulation of appetite.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"25890042","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.isci.2021.103448"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.isci.2021.103448","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"384002"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三宅, 雅人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"泰江, 章博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1252","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヒサナガ, サトシ","creatorNameLang":"ja"},{"creatorName":"ヒサナガ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hisanaga, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツガワ, カズエ","creatorNameLang":"ja"},{"creatorName":"ツガワ, カズエ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsugawa, Kazue","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"阪上, 浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"親泊, 美帆","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"キヨナリ, ヒロシ","creatorNameLang":"ja"},{"creatorName":"キヨナリ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kiyonari, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"親泊, 政一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"305","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-04-21"}],"displaytype":"detail","filename":"isci_24_12_103448.pdf","filesize":[{"value":"3.83 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009787/files/isci_24_12_103448.pdf"},"version_id":"486c29dc-2f31-43df-a233-4451bf335cb0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-21"},"publish_date":"2022-04-21","publish_status":"0","recid":"2009787","relation_version_is_last":true,"title":["Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-18T05:13:43.521890+00:00"}