{"created":"2024-12-12T07:21:27.713372+00:00","id":2009849,"links":{},"metadata":{"_buckets":{"deposit":"19ed967e-78b5-4f9c-b85a-b3082754be02"},"_deposit":{"created_by":7,"id":"2009849","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009849"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009849","sets":["1713853213384:1713853296295:1716268427747:1716268703682"]},"author_link":["1540","615","548","437","834","341","524","1214","176"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"GHSR遺伝子のメチル化に関連するグレリン系バリアントリガンドと受容体の発現は胸腺腫の腫瘍形成を誘導する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"EXPRESSION OF GHRELIN SYSTEM CONSTITUENTS IN THYMIC EPITHELIAL TUMORS","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"793","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Oncology Letters","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Our previous study reported that the DNA methylation of growth hormone secretagogue receptor (GHSR) was significantly higher in thymoma or thymic carcinoma (TC) than in normal thymic tissue samples. Thymic epithelial tumors (TETs) with higher GHSR DNA methylation were associated with significantly worse prognosis than those with lower levels of DNA methylation. Diversified components of the ghrelin‑GHSR axis may exert opposing effects in cancer progression, depending on the cancer type in question. However, the precise function of the axis remains unclear. In the present study, the mRNA expression of five key components of the ghrelin system [native ligand ghrelin, variant ligand In‑1 ghrelin, native receptor GHSR1a, variant receptor GHSR1b and acylation enzyme ghrelin O‑acyltransferase (GOAT)] were examined in 58 TET samples by reverse transcription‑quantitative PCR, and protein expression of GHSR1a and GHSR1b was assessed in 20 TETs using immunohistochemistry. The results revealed that In‑1 ghrelin, GHSR1b (variant forms) and GOAT were more strongly expressed in thymoma compared with thymic‑adjacent tissue. By contrast, no significant differences were observed in the expression of ghrelin and GHSR1a (native forms) between thymoma and thymic tissue. The mRNA expression of In‑1 ghrelin and GHSR1b (variant forms) was positively associated with GHSR methylation in thymoma tissue samples. However, a relationship was not found between ghrelin, GHSR1a or GOAT expression (native forms) and GHSR methylation in thymoma. Immunohistochemical analysis revealed that mRNA expression of GHSR1a and GHSR1b generally correlated with expression of the corresponding protein, and that the expression of GHSR1b was increased in advanced‑stage TETs. These results indicate that the DNA methylation of GHSR is associated with a shift from native expression (ghrelin and GHSR1a) to variant expression (In‑1 ghrelin and GHSR1b), which induces the tumorigenesis of thymoma, but not TC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/)","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17921074","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17921082","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3608号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（保健学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Bilguun Tegsheeの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院保健科学教育部（保健学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲保第56号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3892/ol.2021.13054"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/ol.2021.13054","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"383784"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"テグシー, ビルグーン","creatorNameLang":"ja"},{"creatorName":"テグシー, ビルグーン","creatorNameLang":"ja-Kana"},{"creatorName":"Tegshee, Bilguun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"近藤, 和也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ソエジマ, シホ","creatorNameLang":"ja"},{"creatorName":"ソエジマ, シホ","creatorNameLang":"ja-Kana"},{"creatorName":"Soejima, Shiho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムグルマ, キョウカ","creatorNameLang":"ja"},{"creatorName":"ムグルマ, キョウカ","creatorNameLang":"ja-Kana"},{"creatorName":"Muguruma, Kyoka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"坪井, 光弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"梶浦, 耕一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川上, 行奎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河北, 直也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鳥羽, 博明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 光輝","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝沢, 宏光","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丹黒, 章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"176","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3608_abstract.pdf","filesize":[{"value":"122 KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009849/files/k3608_abstract.pdf"},"version_id":"b50f7e36-3d0c-4b90-8c76-426f3ef08253"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3608_review.pdf","filesize":[{"value":"78.9 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tumors","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"GHSR methylation‑dependent expression of a variant ligand and receptor of the ghrelin system induces thymoma tumorigenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GHSR methylation‑dependent expression of a variant ligand and receptor of the ghrelin system induces thymoma tumorigenesis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268703682"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-11"},"publish_date":"2022-05-11","publish_status":"0","recid":"2009849","relation_version_is_last":true,"title":["GHSR methylation‑dependent expression of a variant ligand and receptor of the ghrelin system induces thymoma tumorigenesis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T07:21:41.078392+00:00"}