{"created":"2024-12-12T07:22:17.419740+00:00","id":2009857,"links":{},"metadata":{"_buckets":{"deposit":"864614ee-d31d-4577-a3ea-a1ec190a67b5"},"_deposit":{"created_by":7,"id":"2009857","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009857"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009857","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["852","1572","781","349","175","1559","287"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"家族性大腸腺腫症における小腸病変と遺伝型-表現型の関係","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Small Intestinal Involvement in FAP","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"34","bibliographicPageStart":"26","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Techniques and Innovations in Gastrointestinal Endoscopy","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND AND AIMS: Small intestinal involvement in familial adenomatous polyposis (FAP) remains unclarified. We performed capsule endoscopy (CE) and balloon-assisted (BA) endoscopy to analyze small intestinal polyps and their genotype-phenotype correlations in a large cohort of FAP patients.\nMETHODS: In this retrospective study, we performed CE in all 149 FAP patients and BA endoscopy in 74 patients with larger polyps. The prevalence of small intestinal adenoma with high-grade dysplasia and cancer was investigated. Correlation between APC variant and polyp phenotype was analyzed.\nRESULTS: Median patient age was 44 years and 69% were male. Pathogenic germline APC variants were found in 117/136 (86.1%). Overall prevalence and median number of small intestinal polyps were 85.2% (127/149) and 17 (IQR 6-36), respectively. A total of 5318 polyps were detected by CE and all 433 polyps histologically examined were confirmed as adenoma. The number of polyps significantly decreased from the proximal-to-distal tracts. Adenoma with high-grade dysplasia was detected in 26.2% (39/149), and its incidence among the polyps was approximately 1.4% (74/5318). Of these, 14 were intramucosal carcinomas with a prevalence of 5.4% (8/149). The germline APC variant in codon 1251-1580 was significantly correlated with a high number of small intestinal polyps. Multivariate analysis revealed APC variant in codon 1251-1580 and a high number of small intestinal polyps as independent risk factors for adenoma with high-grade dysplasia. Spigelman stage was significantly associated with number of jejunal/ileal polyps and their high-grade dysplasia.\nCONCLUSION: Among FAP patients, small intestinal adenoma with high-grade dysplasia was detected in 26.2% and cancer in 5.4%. FAP patients, particularly those with APC variant in codon 1251-1580 and/or high Spigelman stage may require surveillance for small intestinal polyps.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"25900307","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3588号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-16"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Kumiko Tanakaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1529号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.tige.2021.10.001"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.tige.2021.10.001","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"383448"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 久美子","creatorNameLang":"ja"},{"creatorName":"タナカ, クミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Kumiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 康史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イシカワ, ヒデキ","creatorNameLang":"ja"},{"creatorName":"イシカワ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishikawa, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"六車, 直樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺前, 智史","creatorNameLang":"ja"},{"creatorName":"テラマエ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Teramae, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケウチ, ヨウジ","creatorNameLang":"ja"},{"creatorName":"タケウチ, ヨウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeuchi, Yoji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"三井, 康裕","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡本, 耕一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本, 弘志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂東, 良美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ソノダ, トモコ","creatorNameLang":"ja"},{"creatorName":"ソノダ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sonoda, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオミヤ, ナオキ","creatorNameLang":"ja"},{"creatorName":"オオミヤ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohmiya, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムトウ, ミチヒロ","creatorNameLang":"ja"},{"creatorName":"ムトウ, ミチヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Mutoh, Michihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"高山, 哲治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"287","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-19"}],"displaytype":"detail","filename":"k3588_abstract.pdf","filesize":[{"value":"121 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009857/files/k3588_abstract.pdf"},"version_id":"bb714e97-7875-42eb-8246-f58fc665c2cb"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-19"}],"displaytype":"detail","filename":"k3588_review.pdf","filesize":[{"value":"130 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2009857/files/k3588_review.pdf"},"version_id":"cfd1a5a8-a94f-45c5-aa44-dd05434179c6"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-19"}],"displaytype":"detail","filename":"k3588_fulltext.pdf","filesize":[{"value":"1.83 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009857/files/k3588_fulltext.pdf"},"version_id":"7735e532-0140-492f-8be8-95c66d30ba5a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"FAP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"small intestinal polyps","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"capsule endoscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"APC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adenoma with high-grade dysplasia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Multivariate logistic analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spigelman score","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Duodenal polyp","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Small Intestinal Involvement and Genotype-Phenotype Correlation in Familial Adenomatous Polyposis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Small Intestinal Involvement and Genotype-Phenotype Correlation in Familial Adenomatous Polyposis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-19"},"publish_date":"2022-05-19","publish_status":"0","recid":"2009857","relation_version_is_last":true,"title":["Small Intestinal Involvement and Genotype-Phenotype Correlation in Familial Adenomatous Polyposis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T07:22:25.954941+00:00"}