{"created":"2024-12-12T07:23:30.975240+00:00","id":2009872,"links":{},"metadata":{"_buckets":{"deposit":"baf1eb2e-ce48-471a-9168-60bf1b568c9a"},"_deposit":{"created_by":7,"id":"2009872","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009872"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009872","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["892","1589","696"],"control_number":"2009872","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"造影剤濃度と緩和能の定量的パラメータマッピングと脳腫瘍細胞外pH","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2171","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In clinical magnetic resonance imaging, gadolinium-based contrast agents are commonly used for detecting brain tumors and evaluating the extent of malignancy. We present a new method to evaluate relaxivity (r1) and contrast agent concentration separately in contrast-enhanced lesions using quantitative parameter mapping (QPM). Furthermore, we also aimed to estimate the extracellular pH (pHe) of tumor lesions. We demonstrated that it is possible to evaluate pathophysiological tumor changes due to therapeutic efficacy by measuring r1 in contrast-enhanced lesions. In this study, the primary brain tumor group showed significantly higher r1 values than other brain disease groups (P < 0.001). Moreover, mean pHe value showed a trend for tumor malignancy having a lower pHe value and primary brain tumor having a significantly lower pHe than other brain diseases (P < 0.001). Our results might suggest that QPM can separately quantify r1 and CA concentration in brain tumors and that pHe brain tumor mapping could serve as a tumor biomarker. In conclusion, our method has potential clinical applications for assessing the treatment effects.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3599号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1532号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41598-022-05711-z"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-022-05711-z","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"384232"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松元, 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マサフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Masafumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"原田","familyNameLang":"ja"},{"familyName":"ハラダ","familyNameLang":"ja-Kana"},{"familyName":"Harada","familyNameLang":"en"}],"givenNames":[{"givenName":"雅史","givenNameLang":"ja"},{"givenName":"マサフミ","givenNameLang":"ja-Kana"},{"givenName":"Masafumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1589","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60159/profile-ja.html","nameIdentifierScheme":"徳島大学 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Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"金澤","familyNameLang":"ja"},{"familyName":"カナザワ","familyNameLang":"ja-Kana"},{"familyName":"Kanazawa","familyNameLang":"en"}],"givenNames":[{"givenName":"裕樹","givenNameLang":"ja"},{"givenName":"ユウキ","givenNameLang":"ja-Kana"},{"givenName":"Yuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"696","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"277588/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/277588/profile-ja.html"},{"nameIdentifier":"80714013","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80714013"}]},{"creatorNames":[{"creatorName":"タニグチ, ヨウ","creatorNameLang":"ja"},{"creatorName":"タニグチ, ヨウ","creatorNameLang":"ja-Kana"},{"creatorName":"Taniguchi, Yo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オノ, マサハル","creatorNameLang":"ja"},{"creatorName":"オノ, マサハル","creatorNameLang":"ja-Kana"},{"creatorName":"Ono, Masaharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ビトウ, ヨシタカ","creatorNameLang":"ja"},{"creatorName":"ビトウ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Bito, Yoshitaka","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3599_abstract.pdf","filesize":[{"value":"121 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009872/files/k3599_abstract.pdf"},"version_id":"56f5b326-dd5f-46ed-8047-f7376ab4b9ac"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3599_review.pdf","filesize":[{"value":"117 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