{"created":"2024-12-12T07:23:43.952340+00:00","id":2009875,"links":{},"metadata":{"_buckets":{"deposit":"b3f31471-787d-41f2-b897-2a26f65c577b"},"_deposit":{"created_by":7,"id":"2009875","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009875"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009875","sets":["1713853213384:1713853295607"]},"author_link":["851"],"control_number":"2009875","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"SHED-CM for ALS Treatment","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"805379","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Frontiers in Pharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, characterized by the loss of upper and lower motor neurons, for which an effective treatment has yet to be developed. Previous reports have shown that excessive oxidative stress, related to mitochondrial dysfunction and the accumulation of misfolding protein, contributes to ALS pathology. In terms of treatment, it remains necessary to identify effective medicines for multiple therapeutic targets and have additive effects against several disorders. In this study, we investigated stem cells from human exfoliated deciduous teeth (SHED), which release many factors, such as neurotrophic factors and cytokines, and are applied to treat neurological diseases. Specifically, we examined whether SHED-conditioned medium (CM), i.e., the serum-free culture supernatant of SHED, reduced mutant SOD1-induced intracellular aggregates and neurotoxicity. We found that SHED-CM significantly suppressed the mutant SOD1-induced intracellular aggregates and neurotoxicity. The neuroprotective effects of SHED-CM are partly related to heat shock protein and the activation of insulin-like growth factor-1 receptor. SHED-CM also had a protective effect on induced pluripotent stem cell-derived motor neurons. Moreover, SHED-CM was effective against not only familial ALS but also sporadic ALS. Overall, these results suggest that SHED-CM could be a promising treatment for slowing the progression of ALS.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"16639812","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3389/fphar.2022.805379"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fphar.2022.805379","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"385355"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ウエダ, トモユキ","creatorNameLang":"ja"},{"creatorName":"ウエダ, トモユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Tomoyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, タイセイ","creatorNameLang":"ja"},{"creatorName":"イトウ, タイセイ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Taisei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"インデン, マサトシ","creatorNameLang":"ja"},{"creatorName":"インデン, マサトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Inden, Masatoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クリタ, ヒサカ","creatorNameLang":"ja"},{"creatorName":"クリタ, ヒサカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kurita, Hisaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 朗仁","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ホズミ, イサオ","creatorNameLang":"ja"},{"creatorName":"ホズミ, イサオ","creatorNameLang":"ja-Kana"},{"creatorName":"Hozumi, Isao","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-10"}],"displaytype":"detail","filename":"fphar_13_805379.pdf","filesize":[{"value":"3.62 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009875/files/fphar_13_805379.pdf"},"version_id":"c9e82ceb-144e-463a-9edd-4473269af4f5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"amyotrophic lateral sclerosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"copper-zinc superoxide dismutase 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stem cells from human exfoliated deciduous teeth","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"induced pluripotent stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aggregation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-10"},"publish_date":"2022-05-10","publish_status":"0","recid":"2009875","relation_version_is_last":true,"title":["Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-20T00:19:17.282657+00:00"}