{"created":"2024-12-12T07:24:07.326975+00:00","id":2009879,"links":{},"metadata":{"_buckets":{"deposit":"b9cff179-2c04-4472-9856-e0c1be601d10"},"_deposit":{"created_by":7,"id":"2009879","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009879"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009879","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1234","1218","516","567","289","82","1579"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"紫外線発光ダイオードの照射は、そのピーク波長によって異なるウイルス分子を標的にすることで単純ヘルペスウイルスの感染性を減弱する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-14","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"112410","bibliographicVolumeNumber":"228","bibliographic_titles":[{"bibliographic_title":"Journal of Photochemistry and Photobiology B: Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Herpes simplex virus type 1 (HSV-1) is an enveloped virus that mainly infects humans. Given its high global prevalence, disinfection is critical for reducing the risk of infection. Ultraviolet-light-emitting diodes (UV-LEDs) are eco-friendly irradiating modules with different peak wavelengths, but the molecules degraded by UV-LED irradiation have not been clarified. To identify the target viral molecules of UV-LEDs, we exposed HSV-1 suspensions to UV-LED irradiation at wavelengths of 260-, 280-, 310-, and 365-nm and measured viral DNA, protein, and lipid damage and infectivity in host cells. All UV-LEDs substantially reduced by inhibiting host cell transcription, but 260- and 280-nm UV-LEDs had significantly stronger virucidal efficiency than 310- and 365-nm UV-LEDs. Meanwhile, 260- and 280-nm UV-LEDs induced the formation of viral DNA photoproducts and the degradation of viral proteins and some phosphoglycerolipid species. Unlike 260- and 280-nm UV-LEDs, 310- and 365-nm UV-LEDs decreased the viral protein levels, but they did not drastically change the levels of viral DNA photoproducts and lipophilic metabolites. These results suggest that UV-LEDs reduce the infectivity of HSV-1 by targeting different viral molecules based on the peak wavelength. These findings could facilitate the optimization of UV-LED irradiation for viral inactivation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"10111344","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10686173","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11533983","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3602号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Thi Kim Ngan Buiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第290号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.jphotobiol.2022.112410"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jphotobiol.2022.112410","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"390847"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ブイ, ティ キム ガン","creatorNameLang":"ja"},{"creatorName":"ブイ, ティ キム ガン","creatorNameLang":"ja-Kana"},{"creatorName":"Bui, Thi Kim Ngan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"馬渡, 一諭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"榎本, 崇宏","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1218","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"フクシマ, シホ","creatorNameLang":"ja"},{"creatorName":"フクシマ, シホ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukushima, Shiho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"下畑, 隆明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上番増, 喬","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"芥川, 正武","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木内, 陽介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"82","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙橋, 章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1579","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3602_abstract_review.pdf","filesize":[{"value":"177 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009879/files/k3602_abstract_review.pdf"},"version_id":"2a688a95-efad-4720-b112-2760541579d1"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-25"}],"displaytype":"detail","filename":"k3602_fulltext.pdf","filesize":[{"value":"3.45 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009879/files/k3602_fulltext.pdf"},"version_id":"d5bd18c4-b784-4988-b0e5-8aced7a26dbc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"UV-LED","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"herpes simplex virus type 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA photoproducs","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"viral lipids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Light-emitting diode","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":" Ultraviolet ","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"UV-LED irradiation reduces the infectivity of herpes simplex virus type 1 by targeting different viral components depending on the peak wavelength","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"UV-LED irradiation reduces the infectivity of herpes simplex virus type 1 by targeting different viral components depending on the peak wavelength","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-25"},"publish_date":"2022-05-25","publish_status":"0","recid":"2009879","relation_version_is_last":true,"title":["UV-LED irradiation reduces the infectivity of herpes simplex virus type 1 by targeting different viral components depending on the peak wavelength"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T07:24:18.593921+00:00"}