{"created":"2024-12-12T07:25:00.939381+00:00","id":2009890,"links":{},"metadata":{"_buckets":{"deposit":"4df9cb24-25a8-465a-944c-dce397bdf5fd"},"_deposit":{"created_by":7,"id":"2009890","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009890"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009890","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["708","609","1469","345","1524","439"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Biotin levels in blood and follicular fluid","subitem_alternative_title_language":"en"},{"subitem_alternative_title":"血中および卵胞液中ビオチン濃度と体外受精/顕微授精患者における妊娠転帰との関連について","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"69","bibliographicPageStart":"65","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokushima University Faculty of Medicine","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3792号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Rie Yanagiharaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1596号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.69.65"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.69.65","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"397468"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柳原, 里江","creatorNameLang":"ja"},{"creatorName":"ヤナギハラ, リエ","creatorNameLang":"ja-Kana"},{"creatorName":"Yanagihara, Rie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 由理","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河北, 貴子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野口, 拓樹","creatorNameLang":"ja"},{"creatorName":"ノグチ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Noguchi, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤノ, ユウヤ","creatorNameLang":"ja"},{"creatorName":"ヤノ, ユウヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yano, Yuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハヤシ, ノリコ","creatorNameLang":"ja"},{"creatorName":"ハヤシ, ノリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオタ, チアキ","creatorNameLang":"ja"},{"creatorName":"オオタ, チアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohta, Chiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"湊, 沙希","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 周平","creatorNameLang":"ja"},{"creatorName":"カマダ, シュウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamada, Shuhei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アオキ, ヒデノリ","creatorNameLang":"ja"},{"creatorName":"アオキ, ヒデノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Aoki, Hidenori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タムラ, コウ","creatorNameLang":"ja"},{"creatorName":"タムラ, コウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamura, Kou","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マサキ, リエ","creatorNameLang":"ja"},{"creatorName":"マサキ, リエ","creatorNameLang":"ja-Kana"},{"creatorName":"Masaki, Rie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タチバナ, アヤカ","creatorNameLang":"ja"},{"creatorName":"タチバナ, アヤカ","creatorNameLang":"ja-Kana"},{"creatorName":"Tachibana, Ayaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"新垣, 亮輔","creatorNameLang":"ja"},{"creatorName":"アラカキ, リョウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Arakaki, Ryosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉田, 加奈子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 剛志","creatorNameLang":"ja"},{"creatorName":"カトウ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"苛原, 稔","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩佐, 武","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"439","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-22"}],"displaytype":"detail","filename":"k3792_abstract.pdf","filesize":[{"value":"142 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009890/files/k3792_abstract.pdf"},"version_id":"3a60318a-44ba-4412-8036-c20ffed4b9a1"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-22"}],"displaytype":"detail","filename":"k3792_review.pdf","filesize":[{"value":"117 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2009890/files/k3792_review.pdf"},"version_id":"1170a9e0-53d6-4992-9ba2-8d6f2e3e8848"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-22"}],"displaytype":"detail","filename":"k3792_fulltext.pdf","filesize":[{"value":"407 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009890/files/k3792_fulltext.pdf"},"version_id":"e5f16dd5-a052-42f4-a8cb-a21780d56771"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"biotin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IVF/ICSI","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"follicular fluid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pregnancy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-16"},"publish_date":"2022-05-16","publish_status":"0","recid":"2009890","relation_version_is_last":true,"title":["Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T07:25:12.695172+00:00"}