{"created":"2024-12-12T07:26:58.126899+00:00","id":2009914,"links":{},"metadata":{"_buckets":{"deposit":"737863ca-2b29-4b01-b7db-8d12d3ab4a01"},"_deposit":{"created_by":7,"id":"2009914","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009914"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009914","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["527","797","1680","510","1718","1420","630"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"FGF2はヒト歯髄由来間葉系幹細胞においてJNK経路を介してCCL11の発現を抑制する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"FGF2 SUPPRESSED CCL11 EXPRESSION IN HUMAN DENTAL PULP-DERIVED MSCs","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"1356","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Experimental and Therapeutic Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The regulation of the mesenchymal stem cell (MSC) programming mechanism promises great success in regenerative medicine. Tissue regeneration has been associated not only with the differentiation of MSCs, but also with the microenvironment of the stem cell niche that involves various cytokines and immune cells in the tissue regeneration site. In the present study, fibroblast growth factor 2 (FGF2), the principal growth factor for tooth development, dental pulp homeostasis and dentin repair, was reported to affect the expression of cytokines in human dental pulp‑derived MSCs. FGF2 significantly inhibited the expression of chemokine C‑C motif ligand 11 (CCL11) in a time‑ and dose‑dependent manner in the SDP11 human dental pulp‑derived MSC line. This inhibition was diminished following treatment with the AZD4547 FGF receptor (FGFR) inhibitor, indicating that FGF2 negatively regulated the expression of CCL11 in SDP11 cells. Furthermore, FGF2 activated the phosphorylation of p38 mitogen‑activated protein kinase (p38 MAPK), extracellular signal‑regulated kinase 1/2 (ERK1/2) and c‑Jun N‑terminal kinases (JNK) in SDP11 cells. The mechanism of the FGFR‑downstream signaling pathway was then studied using the SB203580, U0126 and SP600125 inhibitors for p38 MAPK, ERK1/2, and JNK, respectively. Interestingly, only treatment with SP600125 blocked the FGF2‑mediated suppression of CCL11. The present results suggested that FGF2 regulated the expression of cytokines and suppressed the expression of CCL11 via the JNK signaling pathway in human dental pulp‑derived MSCs. The present findings could provide important insights into the association of FGF2 and CCL11 in dental tissue regeneration therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. (https://creativecommons.org/licenses/by-nc-nd/4.0/)","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17920981","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17921015","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12610820","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3615号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者RIKA KUROGOUSHIの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第485号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3892/etm.2021.10791"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/etm.2021.10791","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"389304"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黒厚子, 璃佳","creatorNameLang":"ja"},{"creatorName":"クロゴウシ, リカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kurogoushi, Rika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長谷川, 智一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤澤, 友基","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イワタ, ココロ","creatorNameLang":"ja"},{"creatorName":"イワタ, ココロ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Kokoro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"杉本, 明日菜","creatorNameLang":"ja"},{"creatorName":"スギモト, アスナ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugimoto, Asuna","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"上田, 公子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮嵜, 彩","creatorNameLang":"ja"},{"creatorName":"ミヤザキ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyazaki, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Narwidina, Anrizandy","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"河原林, 啓太","creatorNameLang":"ja"},{"creatorName":"カワラバヤシ, ケイタ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawarabayashi, Keita","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"北村, 尚正","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中川, 弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩﨑, 智憲","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩本, 勉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"630","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-06-03"}],"displaytype":"detail","filename":"k3615_abstract.pdf","filesize":[{"value":"130 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009914/files/k3615_abstract.pdf"},"version_id":"105705eb-841f-44f6-b72e-55de3e84be08"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-06-03"}],"displaytype":"detail","filename":"k3615_review.pdf","filesize":[{"value":"59.4 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2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibroblast growth factor receptor signal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"C-C motif ligand 11","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"c-Jun N-terminal kinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Fibroblast growth factor 2 suppresses the expression of C-C motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fibroblast growth factor 2 suppresses the expression of 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