{"created":"2024-12-12T07:33:36.304188+00:00","id":2009991,"links":{},"metadata":{"_buckets":{"deposit":"18536522-d874-485e-aab9-af478b33d1ed"},"_deposit":{"created_by":7,"id":"2009991","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2009991"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02009991","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["838","1623","1622"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"A1型毒素との比較でボツリヌス神経毒素A2型、新規低分子量神経毒素A2NTXの臨床安全性と忍容性","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"824","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Toxins","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"All the botulinum type A neurotoxins available for clinical use are of the A1 subtype. We developed a subtype A2 low-molecular-weight (150 kD (kilo Dalton)) neurotoxin (A2NTX) with less spread and faster entry into the motor nerve terminal than A1 in vitro and in vivo. Preliminary clinical studies showed that its efficacy is superior to A1 toxins. We conducted an open study exploring its safety and tolerability profile in comparison with A1LL (LL type A1 toxin, or onabotulinumtoxinA) and a low-molecular-weight (150 kD) A1 neurotoxin (A1NTX). Those who had been using A1LL (n = 90; 50–360 mouse LD50 units) or A1NTX (n = 30; 50–580 units) were switched to A2NTX (n = 120; 25–600 units) from 2010 to 2018 (number of sessions ~27, cumulative doses ~11,640 units per patient). The adverse events for A2NTX included weakness (n = 1, ascribed to alcoholic polyneuropathy), dysphagia (1), local weakness (4), and spread to other muscles (1), whereas those for A1LL or A1NTX comprised weakness (n = 2, A1NTX), dysphagia (8), ptosis (6), local weakness (7), and spread to other muscles (15). After injections, 89 out of 120 patients preferred A2NTX to A1 for the successive sessions. The present study demonstrated that A2NTX had clinical safety up to the dose of 500 units and was well tolerated compared to A1 toxins","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) License (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20726651","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3638号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-04-28"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Toshiaki Takeuchiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1533号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/toxins13110824"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/toxins13110824","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"386282"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武内, 俊明","creatorNameLang":"ja"},{"creatorName":"タケウチ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeuchi, Toshiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オクノ, ツヨシ","creatorNameLang":"ja"},{"creatorName":"オクノ, ツヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Okuno, Tsuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宮城, 愛","creatorNameLang":"ja"},{"creatorName":"ミヤシロ, アイ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyashiro, Ai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コウダ, トモコ","creatorNameLang":"ja"},{"creatorName":"コウダ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kohda, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宮本, 亮介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和泉, 唯信","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"コザキ, シュンジ","creatorNameLang":"ja"},{"creatorName":"コザキ, シュンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kozaki, Shunji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"梶, 龍兒","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1622","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-06-17"}],"displaytype":"detail","filename":"k3638_abstract.pdf","filesize":[{"value":"128 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2009991/files/k3638_abstract.pdf"},"version_id":"ab1f1425-e748-47c8-be84-3227138694bf"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-06-17"}],"displaytype":"detail","filename":"k3638_review.pdf","filesize":[{"value":"102 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2009991/files/k3638_review.pdf"},"version_id":"94dd2be0-fbb9-4cc7-b50a-ce49cd70c9d5"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-06-17"}],"displaytype":"detail","filename":"k3638_fulltext.pdf","filesize":[{"value":"970 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2009991/files/k3638_fulltext.pdf"},"version_id":"ae802bdb-3dd2-46c6-9460-336908b0997b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"botulinum toxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"subtype A2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clinical tolerability","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"safety","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"patients","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Clinical Safety and Tolerability of A2NTX, a Novel Low-Molecular-Weight Neurotoxin Derived from Botulinum Neurotoxin Subtype A2, in Comparison with Subtype A1 Toxins","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical Safety and Tolerability of A2NTX, a Novel Low-Molecular-Weight Neurotoxin Derived from Botulinum Neurotoxin Subtype A2, in Comparison with Subtype A1 Toxins","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-06-17"},"publish_date":"2022-06-17","publish_status":"0","recid":"2009991","relation_version_is_last":true,"title":["Clinical Safety and Tolerability of A2NTX, a Novel Low-Molecular-Weight Neurotoxin Derived from Botulinum Neurotoxin Subtype A2, in Comparison with Subtype A1 Toxins"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T07:33:46.009056+00:00"}