{"created":"2024-12-12T07:38:25.049750+00:00","id":2010052,"links":{},"metadata":{"_buckets":{"deposit":"244334c6-0a7d-4179-a9a5-b6eb215b3f39"},"_deposit":{"created_by":7,"id":"2010052","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010052"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010052","sets":["1713853213384:1713853295607"]},"author_link":["813","908","805","756","1299","310","924","939","1390"],"control_number":"2010052","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"3566","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Applied Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Shellfish allergy is one of the most common food allergies. Recent studies have shown that sensitization to allergens via the skin is involved in the development of food allergies. In this study, a mouse model of shrimp allergy was generated by epicutaneous sensitization and used to identify skin conditions associated with susceptibility to sensitization. Methods: Four-week-old female BALB/c mice were sensitized by repeated application of 0.1 mg of tropomyosin to tape-stripped skin on days 0, 7, and 15, followed by a challenge on days 28 and 35. Results: Epicutaneously sensitized mice exhibited higher serum levels of tropomyosin-specific IgE on day 15 than control mice. After the oral challenge, model mice had higher anaphylaxis scores and lower rectal temperature. After three tape-strip treatments for sensitization, the skin was analyzed by Raman microscopy. The sensitized mice exhibited lower relative intensities of Raman bands at 399, 915, and 1073 cm−1 than control mice, which could be helpful noninvasive markers in screening for potential sensitization via the skin. Conclusions: An epicutaneous sensitization shellfish allergy model was generated. This model will be useful in studies to elucidate the pathogenesis of skin sensitization. Raman microscopy may also be valuable for capturing subtle skin changes leading to sensitization.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20763417","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/app12073566"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/app12073566","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"384933"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"(市村)清水, 真祐子","creatorNameLang":"ja"},{"creatorName":"(イチムラ)シミズ, マユコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichimura-Shimizu, Mayuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"(市村)清水","familyNameLang":"ja"},{"familyName":"(イチムラ)シミズ","familyNameLang":"ja-Kana"},{"familyName":"Ichimura-Shimizu","familyNameLang":"en"}],"givenNames":[{"givenName":"真祐子","givenNameLang":"ja"},{"givenName":"マユコ","givenNameLang":"ja-Kana"},{"givenName":"Mayuko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"908","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"336324/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/336324/profile-ja.html"}]},{"creatorNames":[{"creatorName":"イシマル, ソウイチロウ","creatorNameLang":"ja"},{"creatorName":"イシマル, ソウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishimaru, Soichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wai, Christine (Yee-Yan)","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"南川, 丈夫","creatorNameLang":"ja"},{"creatorName":"ミナミカワ, タケオ","creatorNameLang":"ja-Kana"},{"creatorName":"Minamikawa, Takeo","creatorNameLang":"en"}],"familyNames":[{"familyName":"南川","familyNameLang":"ja"},{"familyName":"ミナミカワ","familyNameLang":"ja-Kana"},{"familyName":"Minamikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"丈夫","givenNameLang":"ja"},{"givenName":"タケオ","givenNameLang":"ja-Kana"},{"givenName":"Takeo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"805","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"296068/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/296068/profile-ja.html"},{"nameIdentifier":"10637193","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10637193"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"常松, 貴明","creatorNameLang":"ja"},{"creatorName":"ツネマツ, タカアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsunematsu, Takaaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"常松","familyNameLang":"ja"},{"familyName":"ツネマツ","familyNameLang":"ja-Kana"},{"familyName":"Tsunematsu","familyNameLang":"en"}],"givenNames":[{"givenName":"貴明","givenNameLang":"ja"},{"givenName":"タカアキ","givenNameLang":"ja-Kana"},{"givenName":"Takaaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"813","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"304905/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/304905/profile-ja.html"},{"nameIdentifier":"70726752","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70726752"}]},{"creatorNames":[{"creatorName":"エンドウ, アイコ","creatorNameLang":"ja"},{"creatorName":"エンドウ, アイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Endo, Aiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コジマ, タクミ","creatorNameLang":"ja"},{"creatorName":"コジマ, タクミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kojima, Takumi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松本, 穣","creatorNameLang":"ja"},{"creatorName":"マツモト, ミノル","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Minoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"松本","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"穣","givenNameLang":"ja"},{"givenName":"ミノル","givenNameLang":"ja-Kana"},{"givenName":"Minoru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"939","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"346403/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/346403/profile-ja.html"}]},{"creatorNames":[{"creatorName":"小林, 智子","creatorNameLang":"ja"},{"creatorName":"コバヤシ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スミダ, サトシ","creatorNameLang":"ja"},{"creatorName":"スミダ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sumida, Satoshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"柿本, 拓海","creatorNameLang":"ja"},{"creatorName":"カキモト, タクミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kakimoto, Takumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"柿本","familyNameLang":"ja"},{"familyName":"カキモト","familyNameLang":"ja-Kana"},{"familyName":"Kakimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"拓海","givenNameLang":"ja"},{"givenName":"タクミ","givenNameLang":"ja-Kana"},{"givenName":"Takumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮上, 侑子","creatorNameLang":"ja"},{"creatorName":"ミヤカミ, ユウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyakami, Yuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮上","familyNameLang":"ja"},{"familyName":"ミヤカミ","familyNameLang":"ja-Kana"},{"familyName":"Miyakami","familyNameLang":"en"}],"givenNames":[{"givenName":"侑子","givenNameLang":"ja"},{"givenName":"ユウコ","givenNameLang":"ja-Kana"},{"givenName":"Yuko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1390","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"406038/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/406038/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小川, 博久","creatorNameLang":"ja"},{"creatorName":"オガワ, ヒロヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogawa, Hirohisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"小川","familyNameLang":"ja"},{"familyName":"オガワ","familyNameLang":"ja-Kana"},{"familyName":"Ogawa","familyNameLang":"en"}],"givenNames":[{"givenName":"博久","givenNameLang":"ja"},{"givenName":"ヒロヒサ","givenNameLang":"ja-Kana"},{"givenName":"Hirohisa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"310","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174041/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174041/profile-ja.html"},{"nameIdentifier":"50403754","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50403754"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"尾矢, 剛志","creatorNameLang":"ja"},{"creatorName":"オヤ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Oya, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"尾矢","familyNameLang":"ja"},{"familyName":"オヤ","familyNameLang":"ja-Kana"},{"familyName":"Oya","familyNameLang":"en"}],"givenNames":[{"givenName":"剛志","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"924","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"337595/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/337595/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"常山, 幸一","creatorNameLang":"ja"},{"creatorName":"ツネヤマ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuneyama, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"常山","familyNameLang":"ja"},{"familyName":"ツネヤマ","familyNameLang":"ja-Kana"},{"familyName":"Tsuneyama","familyNameLang":"en"}],"givenNames":[{"givenName":"幸一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"289954/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/289954/profile-ja.html"},{"nameIdentifier":"10293341","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10293341"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-07-11"}],"displaytype":"detail","filename":"app_12_7_3566.pdf","filesize":[{"value":"1.25 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010052/files/app_12_7_3566.pdf"},"version_id":"6520fe26-6f41-4581-84be-a7482c96330f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"food allergy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epicutaneous sensitization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"shellfish","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"shrimp","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tropomyosin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"skin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Raman microscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tape-strip","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Establishment of an Epicutaneously Sensitized Murine Model of Shellfish Allergy and Evaluation of Skin Condition by Raman Microscopy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Establishment of an Epicutaneously Sensitized Murine Model of Shellfish Allergy and Evaluation of Skin Condition by Raman Microscopy","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-07-11"},"publish_date":"2022-07-11","publish_status":"0","recid":"2010052","relation_version_is_last":true,"title":["Establishment of an Epicutaneously Sensitized Murine Model of Shellfish Allergy and Evaluation of Skin Condition by Raman Microscopy"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-05-29T02:52:49.253548+00:00"}