| Item type |
文献 / Documents(1) |
| 公開日 |
2023-01-10 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.3164/jcbn.22-37 |
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|
関連名称 |
10.3164/jcbn.22-37 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Protective effects of liposomes encapsulating ferulic acid against CCl4-induced oxidative liver damage in vivo rat model |
| 著者 |
Ara, Tabassum
オノ, サトコ
Hasan, Mahadi
大園, 瑞音
小暮, 健太朗
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| 抄録 |
|
|
内容記述 |
Antioxidants are useful for the treatment of oxidative stress mediated liver damage. A naturally occurring antioxidant γ-oryzanol is rapidly hydrolyzed to its active hydrophobic metabolite, ferulic acid, inside the body. Limitations associated with the hydrophobicity of ferulic acid can be overcome by encapsulating in a liposomal formulation. As intravenously administered nanoparticles (including liposomes) can effectively reach the liver, such systems may be suitable drug delivery carriers to treat liver injury. In this study, we prepared a liposomal formulation of ferulic acid (ferulic-lipo) and examined its effects on liver damage induced by CCl4. Ferulic-lipo were ~100 nm in size and drug encapsulation efficiency was about 92%. Ferulic-lipo showed potent scavenging efficacy against hydroxyl radical compared to α-tocopherol liposomes. Ferulic-lipo significantly prevented CCl4-mediated cytotoxicity in human hepatocarcinoma cells. Furthermore, intravenous administration of ferulic-lipo significantly reduced alanine aminotransferase and aspartate amino transferase levels in a rat model of liver injury. CCl4-mediated reactive oxygen species generation in liver was also reduced by intravenous administration of ferulic-lipo. Hepatoprotective effects of ferulic-lipo were demonstrated by histological observation of CCl4-induced liver tissue damage. Therefore, ferulic-lipo exhibit potent antioxidative capacity and were suggested to be an effective formulation for prevention of oxidative damage of liver tissue. |
| キーワード |
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|
主題 |
ferulic acid |
| キーワード |
|
|
主題 |
liver toxicity |
| キーワード |
|
|
主題 |
CCl4 |
| キーワード |
|
|
主題 |
liposome |
| キーワード |
|
|
主題 |
oxidative stress |
| 書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition
巻 72,
号 1,
p. 46-53,
発行日 2023-01-01
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09120009 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18805086 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10710201 |
| 出版者 |
|
|
出版者 |
Society for Free Radical Research Japan |
| 権利情報 |
|
|
権利情報 |
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
386965 |
| 言語 |
|
|
言語 |
eng |
jcbn_72_1_46.pdf (2.79 MB)
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