{"created":"2024-12-12T07:42:51.021397+00:00","id":2010107,"links":{},"metadata":{"_buckets":{"deposit":"3e5591b2-983c-40bd-9782-9dc3804ee813"},"_deposit":{"created_by":7,"id":"2010107","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010107"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010107","sets":["1713853213384:1713853295607"]},"author_link":["750","248","479"],"control_number":"2010107","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"19","bibliographicPageStart":"10831","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Circadian phase shifts in peripheral clocks induced by changes in feeding rhythm often result in insulin resistance. However, whether the hypothalamic control system for energy metabolism is involved in the feeding rhythm-related development of insulin resistance is unknown. Here, we show the physiological significance and mechanism of the involvement of the agouti-related protein (AgRP) in evening feeding-associated alterations in insulin sensitivity. Evening feeding during the active dark period increased hypothalamic AgRP expression and skeletal muscle insulin resistance in mice. Inhibiting AgRP expression by administering an antisense oligo or a glucocorticoid receptor antagonist mitigated these effects. AgRP-producing neuron-specific glucocorticoid receptor-knockout (AgRP-GR-KO) mice had normal skeletal muscle insulin sensitivity even under evening feeding schedules. Hepatic vagotomy enhanced AgRP expression in the hypothalamus even during ad-lib feeding in wild-type mice but not in AgRP-GR-KO mice. The findings of this study indicate that feeding in the late active period may affect hypothalamic AgRP expression via glucocorticoids and induce skeletal muscle insulin resistance.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Tetsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"志内","familyNameLang":"ja"},{"familyName":"シウチ","familyNameLang":"ja-Kana"},{"familyName":"Shiuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"哲也","givenNameLang":"ja"},{"givenName":"テツヤ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"219491/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/219491/profile-ja.html"},{"nameIdentifier":"70372729","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70372729"}]},{"creatorNames":[{"creatorName":"オオツカ, アイリ","creatorNameLang":"ja"},{"creatorName":"オオツカ, アイリ","creatorNameLang":"ja-Kana"},{"creatorName":"Otsuka, Airi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"清水, 紀之","creatorNameLang":"ja"},{"creatorName":"シミズ, ノリユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimizu, Noriyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"清水","familyNameLang":"ja"},{"familyName":"シミズ","familyNameLang":"ja-Kana"},{"familyName":"Shimizu","familyNameLang":"en"}],"givenNames":[{"givenName":"紀之","givenNameLang":"ja"},{"givenName":"ノリユキ","givenNameLang":"ja-Kana"},{"givenName":"Noriyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"750","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70755470","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70755470"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"近久, 幸子","creatorNameLang":"ja"},{"creatorName":"チカヒサ, サチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Chikahisa, Sachiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"近久","familyNameLang":"ja"},{"familyName":"チカヒサ","familyNameLang":"ja-Kana"},{"familyName":"Chikahisa","familyNameLang":"en"}],"givenNames":[{"givenName":"幸子","givenNameLang":"ja"},{"givenName":"サチコ","givenNameLang":"ja-Kana"},{"givenName":"Sachiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"248","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00452649","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00452649"}]},{"creatorNames":[{"creatorName":"セイ, ヒロヨシ","creatorNameLang":"ja"},{"creatorName":"セイ, ヒロヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Séi, Hiroyoshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-08-01"}],"displaytype":"detail","filename":"ijms_22_19_10831.pdf","filesize":[{"value":"3.04 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muscle","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-01"},"publish_date":"2022-08-01","publish_status":"0","recid":"2010107","relation_version_is_last":true,"title":["Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-10T06:26:03.403383+00:00"}