{"created":"2024-12-12T07:42:55.195000+00:00","id":2010108,"links":{},"metadata":{"_buckets":{"deposit":"1940dafc-45ab-4256-8d47-c2b01fea0d13"},"_deposit":{"created_by":7,"id":"2010108","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010108"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010108","sets":["1713853213384:1713853295607"]},"author_link":["908","756","1637","1542","310"],"control_number":"2010108","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"404","bibliographicPageStart":"395","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"Allergology International","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Refractory asthma, which is caused by several factors including neutrophil infiltration is a serious complication of bronchial asthma. We previously reported that nerve growth factor (NGF) is involved in AHR. NGF-derived induction of hyperalgesia is dependent on neutrophils; however, this relationship remains unclear in respiratory disease. In this study, we examined the roles of neutrophils and NGF in refractory asthma.\nMethods: Using intranasal house dust mite sensitization, we established a mouse model of asthma with mixed inflammation (Mix-in). AHR, NGF production and hyperinnervation of the lungs were examined with or without different inhibitory treatments. The levels of the singlet oxygen markers, 10- and 12-(Z,E)-hydroxyoctadecadienoic acids (HODE) in the lungs, were measured by liquid chromatography-tandem mass spectrometry. An in vitro experiment was also performed to evaluate the direct effect of singlet oxygen on NGF production.\nResults: NGF production and hyperinnervation were higher in Mix-in mice than in conventional eosinophilic-asthmatic mice and were positively correlated with AHR. Asthmatic parameters were inhibited by NGF neutralizing Abs and myeloperoxidase (MPO) inhibition. The 10- and 12-(Z,E)-HODEs levels were increased in the lungs and were positively correlated with MPO activity and NGF production. NGF was produced by bronchial epithelial cells in vitro upon stimulation with singlet oxygen.\nConclusions: Our findings suggest that neutrophil MPO-derived singlet oxygen induces increased NGF production, leading to AHR and 10- and 12-(Z,E)-HODEs production. These findings may help to develop new therapies targeting this mechanism and to establish a new biomarker for non-type 2 and refractory asthma.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Allergology","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13238930","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11091750","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.alit.2022.02.005"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.alit.2022.02.005","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"386949"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小川, 博久","creatorNameLang":"ja"},{"creatorName":"オガワ, ヒロヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogawa, Hirohisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"小川","familyNameLang":"ja"},{"familyName":"オガワ","familyNameLang":"ja-Kana"},{"familyName":"Ogawa","familyNameLang":"en"}],"givenNames":[{"givenName":"博久","givenNameLang":"ja"},{"givenName":"ヒロヒサ","givenNameLang":"ja-Kana"},{"givenName":"Hirohisa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"310","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174041/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174041/profile-ja.html"},{"nameIdentifier":"50403754","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50403754"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吾妻, 雅彦","creatorNameLang":"ja"},{"creatorName":"アヅマ, マサヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Azuma, Masahiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"吾妻","familyNameLang":"ja"},{"familyName":"アヅマ","familyNameLang":"ja-Kana"},{"familyName":"Azuma","familyNameLang":"en"}],"givenNames":[{"givenName":"雅彦","givenNameLang":"ja"},{"givenName":"マサヒコ","givenNameLang":"ja-Kana"},{"givenName":"Masahiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1637","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80325282","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80325282"}]},{"creatorNames":[{"creatorName":"ウメノ, アヤ","creatorNameLang":"ja"},{"creatorName":"ウメノ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Umeno, Aya","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"(市村)清水, 真祐子","creatorNameLang":"ja"},{"creatorName":"(イチムラ)シミズ, マユコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichimura-Shimizu, Mayuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"(市村)清水","familyNameLang":"ja"},{"familyName":"(イチムラ)シミズ","familyNameLang":"ja-Kana"},{"familyName":"Ichimura-Shimizu","familyNameLang":"en"}],"givenNames":[{"givenName":"真祐子","givenNameLang":"ja"},{"givenName":"マユコ","givenNameLang":"ja-Kana"},{"givenName":"Mayuko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"908","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"336324/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/336324/profile-ja.html"}]},{"creatorNames":[{"creatorName":"ムロトミ, カズトシ","creatorNameLang":"ja"},{"creatorName":"ムロトミ, カズトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Murotomi, Kazutoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシダ, ヤスカズ","creatorNameLang":"ja"},{"creatorName":"ヨシダ, ヤスカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Yasukazu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西岡, 安彦","creatorNameLang":"ja"},{"creatorName":"ニシオカ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishioka, Yasuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西岡","familyNameLang":"ja"},{"familyName":"ニシオカ","familyNameLang":"ja-Kana"},{"familyName":"Nishioka","familyNameLang":"en"}],"givenNames":[{"givenName":"安彦","givenNameLang":"ja"},{"givenName":"ヤスヒコ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60062/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60062/profile-ja.html"},{"nameIdentifier":"70274199","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70274199"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"常山, 幸一","creatorNameLang":"ja"},{"creatorName":"ツネヤマ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuneyama, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"常山","familyNameLang":"ja"},{"familyName":"ツネヤマ","familyNameLang":"ja-Kana"},{"familyName":"Tsuneyama","familyNameLang":"en"}],"givenNames":[{"givenName":"幸一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"289954/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/289954/profile-ja.html"},{"nameIdentifier":"10293341","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10293341"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-08-02"}],"displaytype":"detail","filename":"alit_71_3_395.pdf","filesize":[{"value":"1.89 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010108/files/alit_71_3_395.pdf"},"version_id":"6fc5be9f-8e4e-4926-abdd-b3438003baa6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Airway hyperresponsiveness","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nerve growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Refractory asthma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Singlet oxygen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"10- and 12-(Z,E)-hydroxyoctadecadienoic acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-02"},"publish_date":"2022-08-02","publish_status":"0","recid":"2010108","relation_version_is_last":true,"title":["Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T06:41:48.554531+00:00"}