{"created":"2024-12-12T07:43:44.812902+00:00","id":2010118,"links":{},"metadata":{"_buckets":{"deposit":"2d1be275-9aa2-465d-babd-049d8d97f5ca"},"_deposit":{"created_by":7,"id":"2010118","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010118"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010118","sets":["1713853213384:1713853295607"]},"author_link":["1400","1475","969","1542","815"],"control_number":"2010118","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"373","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"BMC Pulmonary Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Nivolumab is used for the treatment of malignant pleural mesothelioma (MPM). However, immune-related adverse events (irAEs) occur in patients treated with nivolumab. Several studies have reported the correlation between irAEs and therapeutic effects of immune checkpoint inhibitor, but none have reported the correlation in MPM. Here we report a retrospective study which shows the correlation between irAEs and therapeutic effects of nivolumab in patients with MPM.\nMethods: This study included patients treated with nivolumab at Tokushima University Hospital from February 2009 to September 2021. We retrospectively reviewed the medical records to evaluate the several clinical factors, such as the presence or absence of irAEs, their severities, progression-free survival (PFS), overall survival (OS) or objective response to the treatment.\nResults: Eleven patients received treatment with nivolumab. Objective response rate was 18.2% and the disease control rate was 90.9%. Median PFS was 6.8 months (95% confidence interval, 1.3 to 11.9 months) and median OS was 15.2 months (95% confidence interval, 8.9 to 21.5 months). IrAEs occurred in eight patients (72.7%), and grade ≥ 2 irAEs occurred in six patients (54.5%). PFS and OS were significantly longer in the grade ≥ 2 irAEs group than in grade < 2 irAEs group (median PFS 13.6 vs. 3.8 months, p = 0.0093; median OS not reached vs. 8.6 months, p = 0.0108).\nConclusions: This is the first study to report the correlation between irAEs and therapeutic effects in patients with MPM. Because the presence of irAEs may be associated with a favorable clinical outcome, early detection and appropriate management of irAEs will increase the therapeutic benefits to patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14712466","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12035438","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s12890-021-01746-6"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12890-021-01746-6","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"387235"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"米田, 浩人","creatorNameLang":"ja"},{"creatorName":"ヨネダ, ヒロト","creatorNameLang":"ja-Kana"},{"creatorName":"Yoneda, Hiroto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"軒原, 浩","creatorNameLang":"ja"},{"creatorName":"ノキハラ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nokihara, 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Yohei","creatorNameLang":"en"}],"familyNames":[{"familyName":"矢葺","familyNameLang":"ja"},{"familyName":"ヤブキ","familyNameLang":"ja-Kana"},{"familyName":"Yabuki","familyNameLang":"en"}],"givenNames":[{"givenName":"洋平","givenNameLang":"ja"},{"givenName":"ヨウヘイ","givenNameLang":"ja-Kana"},{"givenName":"Yohei","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1400","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"406057/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/406057/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"荻野, 広和","creatorNameLang":"ja"},{"creatorName":"オギノ, ヒロカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogino, Hirokazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"荻野","familyNameLang":"ja"},{"familyName":"オギノ","familyNameLang":"ja-Kana"},{"familyName":"Ogino","familyNameLang":"en"}],"givenNames":[{"givenName":"広和","givenNameLang":"ja"},{"givenName":"ヒロカズ","givenNameLang":"ja-Kana"},{"givenName":"Hirokazu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"815","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"304924/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/304924/profile-ja.html"},{"nameIdentifier":"20745294","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20745294"}]},{"creatorNames":[{"creatorName":"大塚, 憲司","creatorNameLang":"ja"},{"creatorName":"オオツカ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Otsuka, Kenji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西岡, 安彦","creatorNameLang":"ja"},{"creatorName":"ニシオカ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishioka, Yasuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西岡","familyNameLang":"ja"},{"familyName":"ニシオカ","familyNameLang":"ja-Kana"},{"familyName":"Nishioka","familyNameLang":"en"}],"givenNames":[{"givenName":"安彦","givenNameLang":"ja"},{"givenName":"ヤスヒコ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60062/profile-ja.html","nameIdentifierScheme":"徳島大学 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mesothelioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nivolumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Therapeutic effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Correlation between immune-related adverse events and therapeutic effects of nivolumab in patients with malignant pleural mesothelioma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Correlation between immune-related adverse events and therapeutic effects of nivolumab in patients with malignant pleural mesothelioma","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-04"},"publish_date":"2022-08-04","publish_status":"0","recid":"2010118","relation_version_is_last":true,"title":["Correlation between immune-related adverse events and therapeutic effects of nivolumab in patients with malignant pleural mesothelioma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:43:39.793578+00:00"}