{"created":"2024-12-12T07:45:50.965189+00:00","id":2010147,"links":{},"metadata":{"_buckets":{"deposit":"804b1c3e-8510-41fa-b5a5-e3d02c63097f"},"_deposit":{"created_by":7,"id":"2010147","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010147"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010147","sets":["1713853213384:1713853295607"]},"author_link":["939","1118","924","608","756"],"control_number":"2010147","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"PHENOTYPIC ANALYSIS OF MICE DEFICIENT FOR Ly6C1/Ly6C2","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"210","bibliographicPageStart":"202","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"ImmunoHorizons","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ly6C comprises two homologous components of Ly6C1 and Ly6C2, and the expression of either of the Ly6C molecules defines unique functional subsets of monocytes. Ly6C is also expressed by other immune cell types, including Aire-expressing medullary thymic epithelial cells. Because the role of Ly6C expression in determining the functional subsets remains unclear, we generated mice deficient for both Ly6C1 and Ly6C2 with CRISPR-Cas9–mediated deletion. Mice deficient for Ly6C1/Ly6C2 showed no major alterations in the subsets and function of monocyte and other immune cells, including the cells involved in the dextran sulfate sodium salt–induced colitis model. By generating the mice deficient for Ly6C1 alone, we have also investigated the expression pattern of Ly6C1 and Ly6C2 in immune cells. Except for medullary thymic epithelial cells and CD4 single-positive T cells, immune cells predominantly expressed Ly6C2. Thus, despite the importance as a marker with a unique differential expression pattern, the Ly6C molecules have no major impact on determining the functional subsets and maintaining immune homeostasis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The American Association of Immunologists","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is distributed under the terms of the CC BY 4.0 Unported license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"25737732","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.4049/immunohorizons.2100114"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4049/immunohorizons.2100114","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"384535"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"森本, 純子","creatorNameLang":"ja"},{"creatorName":"モリモト, ジュンコ","creatorNameLang":"ja-Kana"},{"creatorName":"Morimoto, Junko","creatorNameLang":"en"}],"familyNames":[{"familyName":"森本","familyNameLang":"ja"},{"familyName":"モリモト","familyNameLang":"ja-Kana"},{"familyName":"Morimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"純子","givenNameLang":"ja"},{"givenName":"ジュンコ","givenNameLang":"ja-Kana"},{"givenName":"Junko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"261259/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/261259/profile-ja.html"},{"nameIdentifier":"20451396","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20451396"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松本, 穣","creatorNameLang":"ja"},{"creatorName":"マツモト, ミノル","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Minoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"松本","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"穣","givenNameLang":"ja"},{"givenName":"ミノル","givenNameLang":"ja-Kana"},{"givenName":"Minoru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"939","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"346403/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/346403/profile-ja.html"}]},{"creatorNames":[{"creatorName":"宮澤, 龍一郎","creatorNameLang":"ja"},{"creatorName":"ミヤザワ, リュウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyazawa, Ryuichiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"尾矢, 剛志","creatorNameLang":"ja"},{"creatorName":"オヤ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Oya, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"尾矢","familyNameLang":"ja"},{"familyName":"オヤ","familyNameLang":"ja-Kana"},{"familyName":"Oya","familyNameLang":"en"}],"givenNames":[{"givenName":"剛志","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"924","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"337595/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/337595/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"常山, 幸一","creatorNameLang":"ja"},{"creatorName":"ツネヤマ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuneyama, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"常山","familyNameLang":"ja"},{"familyName":"ツネヤマ","familyNameLang":"ja-Kana"},{"familyName":"Tsuneyama","familyNameLang":"en"}],"givenNames":[{"givenName":"幸一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"289954/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/289954/profile-ja.html"},{"nameIdentifier":"10293341","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10293341"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松本, 満","creatorNameLang":"ja"},{"creatorName":"マツモト, ミツル","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Mitsuru","creatorNameLang":"en"}],"familyNames":[{"familyName":"松本","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"満","givenNameLang":"ja"},{"givenName":"ミツル","givenNameLang":"ja-Kana"},{"givenName":"Mitsuru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1118","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60604/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60604/profile-ja.html"},{"nameIdentifier":"60221595","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60221595"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-08-09"}],"displaytype":"detail","filename":"immuno_6_3_202.pdf","filesize":[{"value":"1.19 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010147/files/immuno_6_3_202.pdf"},"version_id":"0112ad65-d932-4cf4-bc8c-2d48382f8a35"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"No Major Impact of Two Homologous Proteins Ly6C1 and Ly6C2 on Immune Homeostasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"No Major Impact of Two Homologous Proteins Ly6C1 and Ly6C2 on Immune Homeostasis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-09"},"publish_date":"2022-08-09","publish_status":"0","recid":"2010147","relation_version_is_last":true,"title":["No Major Impact of Two Homologous Proteins Ly6C1 and Ly6C2 on Immune Homeostasis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-30T06:51:37.744250+00:00"}