{"created":"2024-12-12T07:47:24.340952+00:00","id":2010165,"links":{},"metadata":{"_buckets":{"deposit":"c3193689-bc2d-4edc-9d21-2dddc9d2d28f"},"_deposit":{"created_by":7,"id":"2010165","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010165"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010165","sets":["1713853213384:1713853295607"]},"author_link":["322","1542","815"],"control_number":"2010165","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"e151239","bibliographicVolumeNumber":"132","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND. Long-term prognosis of WHO grade II low-grade gliomas (LGGs) is poor, with a high risk of recurrence and malignant transformation into high-grade gliomas. Given the relatively intact immune system of patients with LGGs and the slow tumor growth rate, vaccines are an attractive treatment strategy.\nMETHODS. We conducted a pilot study to evaluate the safety and immunological effects of vaccination with GBM6-AD, lysate of an allogeneic glioblastoma stem cell line, with poly-ICLC in patients with LGGs. Patients were randomized to receive the vaccines before surgery (arm 1) or not (arm 2) and all patients received adjuvant vaccines. Coprimary outcomes were to evaluate safety and immune response in the tumor.\nRESULTS. A total of 17 eligible patients were enrolled — 9 in arm 1 and 8 in arm 2. This regimen was well tolerated with no regimen-limiting toxicity. Neoadjuvant vaccination induced upregulation of type-1 cytokines and chemokines and increased activated CD8+ T cells in peripheral blood. Single-cell RNA/T cell receptor sequencing detected CD8+ T cell clones that expanded with effector phenotype and migrated into the tumor microenvironment (TME) in response to neoadjuvant vaccination. Mass cytometric analyses detected increased tissue resident–like CD8+ T cells with effector memory phenotype in the TME after the neoadjuvant vaccination.\nCONCLUSION. The regimen induced effector CD8+ T cell response in peripheral blood and enabled vaccine-reactive CD8+ T cells to migrate into the TME. Further refinements of the regimen may have to be integrated into future strategies.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00219738","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15588238","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12034468","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1172/JCI151239"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1172/JCI151239","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"387240"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"荻野, 広和","creatorNameLang":"ja"},{"creatorName":"オギノ, ヒロカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogino, Hirokazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"荻野","familyNameLang":"ja"},{"familyName":"オギノ","familyNameLang":"ja-Kana"},{"familyName":"Ogino","familyNameLang":"en"}],"givenNames":[{"givenName":"広和","givenNameLang":"ja"},{"givenName":"ヒロカズ","givenNameLang":"ja-Kana"},{"givenName":"Hirokazu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"815","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"304924/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/304924/profile-ja.html"},{"nameIdentifier":"20745294","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20745294"}]},{"creatorNames":[{"creatorName":"Taylor, Jennie W.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ネジョウ, タカヒデ","creatorNameLang":"ja"},{"creatorName":"ネジョウ, タカヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Nejo, Takahide","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gibson, David","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watchmaker, Payal B.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカダ, カオリ","creatorNameLang":"ja"},{"creatorName":"オカダ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Kaori","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西條, 敦郎","creatorNameLang":"ja"},{"creatorName":"サイジョウ, アツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Saijo, Atsuro","creatorNameLang":"en"}],"familyNames":[{"familyName":"西條","familyNameLang":"ja"},{"familyName":"サイジョウ","familyNameLang":"ja-Kana"},{"familyName":"Saijo","familyNameLang":"en"}],"givenNames":[{"givenName":"敦郎","givenNameLang":"ja"},{"givenName":"アツロウ","givenNameLang":"ja-Kana"},{"givenName":"Atsuro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"322","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00467812","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00467812"}]},{"creatorNames":[{"creatorName":"Tedesco, Meghan R.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shai, Anny","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wong, Cynthia M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Rabbitt, Jane E.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Olin, Michael R.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Moertel, Christopher L.","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西岡, 安彦","creatorNameLang":"ja"},{"creatorName":"ニシオカ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishioka, Yasuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西岡","familyNameLang":"ja"},{"familyName":"ニシオカ","familyNameLang":"ja-Kana"},{"familyName":"Nishioka","familyNameLang":"en"}],"givenNames":[{"givenName":"安彦","givenNameLang":"ja"},{"givenName":"ヤスヒコ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60062/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60062/profile-ja.html"},{"nameIdentifier":"70274199","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70274199"}]},{"creatorNames":[{"creatorName":"Salazar, Andres M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Molinaro, Annette M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Phillips, Joanna J.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Butowski, Nicholas A.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Clarke, Jennifer L.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Oberheim Bush, Nancy Ann","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hervey-Jumper, Shawn L.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Theodosopoulos, Philip","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chang, Susan M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Berger, Mitchel S.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカダ, ヒデホ","creatorNameLang":"ja"},{"creatorName":"オカダ, ヒデホ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Hideho","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-08-23"}],"displaytype":"detail","filename":"jci_132_3_e151239.pdf","filesize":[{"value":"4.05 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010165/files/jci_132_3_e151239.pdf"},"version_id":"4a358615-5564-4f39-8909-c6d67375f626"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-23"},"publish_date":"2022-08-23","publish_status":"0","recid":"2010165","relation_version_is_last":true,"title":["Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:42:41.642336+00:00"}