{"created":"2024-12-12T07:49:37.006044+00:00","id":2010188,"links":{},"metadata":{"_buckets":{"deposit":"4c68b473-af9a-4d34-abe7-7308925abd21"},"_deposit":{"created_by":7,"id":"2010188","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010188"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010188","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1005","818","1496","1418","1415","943","521","1636","228"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ビッグデータ解析を用いたドキソルビシン誘導心イベントに対する予防薬の探索","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"175083","bibliographicVolumeNumber":"928","bibliographic_titles":[{"bibliographic_title":"European Journal of Pharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: Doxorubicin, an anthracycline anti-tumour agent, is an essential chemotherapeutic drug; however, the adverse events associated with doxorubicin usage, including cardiotoxicity, prevent patients from continuing treatment. Here, we used databases to explore existing approved drugs with potential preventative effects against doxorubicin-induced cardiac events and examined their efficacy and mechanisms.\nMethods: The Gene Expression Omnibus (GEO), Library of Integrated Network-based Cellular Signatures (LINCS), and Food and Drug Administration Adverse Events Reporting System (FAERS) databases were used to extract candidate prophylactic drugs. Mouse models of doxorubicin-induced cardiac events were generated by intraperitoneal administration of 20 mg/kg of doxorubicin on Day 1 and oral administration of prophylactic candidate drugs for 6 consecutive days beginning the day before doxorubicin administration. On Day 6, mouse hearts were extracted and examined for mRNA expression of apoptosis-related genes.\nResults: GEO analysis showed that doxorubicin administration upregulated 490 genes and downregulated 862 genes, and LINCS data identified sirolimus, verapamil, minoxidil, prednisolone, guanabenz, and mosapride as drugs capable of counteracting these genetic alterations. Examination of the effects of these drugs on cardiac toxicity using FAERS identified sirolimus and mosapride as new prophylactic drug candidates. In model mice, mosapride and sirolimus suppressed the Bax/Bcl-2 mRNA ratio, which is elevated in doxorubicin-induced cardiotoxicity. These drugs also suppressed the expression of inflammatory cytokines Il1b and Il6 and markers associated with myocardial fibrosis, including Lgal3 and Timp1.\nConclusion: These findings suggest that doxorubicin-induced cardiac events are suppressed by the administration of mosapride and sirolimus.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00142999","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00639687","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11527211","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3698号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Shiori Nishiuchiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1567号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.ejphar.2022.175083"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ejphar.2022.175083","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"390279"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西内, 栞","creatorNameLang":"ja"},{"creatorName":"ニシウチ, シオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishiuchi, Shiori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"八木, 健太","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"サイトウ, ヒロウミ","creatorNameLang":"ja"},{"creatorName":"サイトウ, ヒロウミ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Hiroumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"座間味, 義人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"新村, 貴博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ミヤタ, コウジ","creatorNameLang":"ja"},{"creatorName":"ミヤタ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyata, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サカモト, ヨシカ","creatorNameLang":"ja"},{"creatorName":"サカモト, ヨシカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakamoto, Yoshika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フクナガ, キミコ","creatorNameLang":"ja"},{"creatorName":"フクナガ, キミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukunaga, Kimiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシダ, シュンスケ","creatorNameLang":"ja"},{"creatorName":"イシダ, シュンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishida, Shunsuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"濱野, 裕章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相澤, 風花","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"合田, 光寛","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中馬, 真幸","creatorNameLang":"ja"},{"creatorName":"チュウマ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Chuma, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"(井澤)石澤, 有紀","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ナワ, ヒデキ","creatorNameLang":"ja"},{"creatorName":"ナワ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nawa, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楊河, 宏章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カンダ, ヤスナリ","creatorNameLang":"ja"},{"creatorName":"カンダ, ヤスナリ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanda, Yasunari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石澤, 啓介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"228","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3698_abstract.pdf","filesize":[{"value":"137 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2010188/files/k3698_abstract.pdf"},"version_id":"6de69f30-e83b-497e-8d47-0ea21a336540"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3698_review.pdf","filesize":[{"value":"89.4 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2010188/files/k3698_review.pdf"},"version_id":"3f352769-40ce-4f0b-ba2b-ee5362da40e6"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3698_fulltext.pdf","filesize":[{"value":"594 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010188/files/k3698_fulltext.pdf"},"version_id":"5fd7c47e-09f7-4a79-87f0-01edc7af1d93"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Drug–drug interaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Data analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Doxorubicin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Investigation of drugs for the prevention of doxorubicin-induced cardiac events using big data analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigation of drugs for the prevention of doxorubicin-induced cardiac events using big data analysis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-23"},"publish_date":"2022-08-23","publish_status":"0","recid":"2010188","relation_version_is_last":true,"title":["Investigation of drugs for the prevention of doxorubicin-induced cardiac events using big data analysis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T07:49:47.168693+00:00"}