{"created":"2024-12-12T07:49:57.201224+00:00","id":2010192,"links":{},"metadata":{"_buckets":{"deposit":"39a48b02-f0a2-4181-8ed9-759ff2e187ef"},"_deposit":{"created_by":7,"id":"2010192","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010192"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010192","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["564","800","540","231","413","340","197","183","1159","309"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"選択的ミネラルコルチコイド受容体遮断薬であるエサキセレノンは、高脂肪食投与マウスにおけるインスリン感受性を改善する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-08-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"175190","bibliographicVolumeNumber":"931","bibliographic_titles":[{"bibliographic_title":"European Journal of Pharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Esaxerenone is a novel, non-steroidal selective mineralocorticoid receptor (MR) blocker. MR activation plays a crucial role in the development of cardiovascular and metabolic diseases. In this study, we investigated the effects of esaxerenone on various metabolic parameters in mice.\nMaterials and methods: Esaxerenone (3 mg/kg/day) was orally administered to high-fat diet (HFD)-fed male C57BL/6 mice. Mice fed a normal diet (ND) served as controls. Glucose and insulin tolerance, plasma lipid levels, and transaminase levels were assessed as metabolic parameters. Macrophage accumulation in the adipose tissue was evaluated using histological analysis. 3T3-L1 adipocytes, HepG2 cells, and C2C12 myotubes were used for in vitro experiments. Gene expression and insulin signaling were examined using quantitative RT-PCR and western blotting, respectively.\nResults: HFD successfully induced insulin resistance compared with that in ND. Esaxerenone ameliorated insulin resistance (P < 0.05) without altering other metabolic parameters, such as the lipid profile. Esaxerenone administration tended to decrease plasma transaminase levels compared with those in the non-treated group. In the adipose tissue, esaxerenone decreased macrophage accumulation (P < 0.05) and increased the expression levels of adiponectin and PPARγ. Aldosterone significantly decreased the expression levels of PPARγ and adiponectin in 3T3-L1 adipocytes. Furthermore, aldosterone attenuated insulin-induced Akt phosphorylation in 3T3-L1 adipocytes, HepG2 cells, and C2C12 myotubes in a dose-dependent manner (P < 0.01). These effects were ameliorated by pretreatment with esaxerenone.\nConclusion: Esaxerenone ameliorated insulin resistance in HFD-fed mice. Reduction of inflammation and improvement in insulin signaling may underlie the beneficial effects of esaxerenone.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00142999","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18790712","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00639687","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11527211","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3756号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-09-30"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Oyunbileg Bavuuの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1581号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.ejphar.2022.175190"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ejphar.2022.175190","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"389452"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"バヴー, オイウンビレグ","creatorNameLang":"ja"},{"creatorName":"バヴー, オイウンビレグ","creatorNameLang":"ja-Kana"},{"creatorName":"Bavuu, Oyunbileg","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"福田, 大受","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ganbaatar, Byambasuren","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松浦, 朋美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊勢, 孝之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"楠瀬, 賢也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口, 浩司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"八木, 秀介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 博胤","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"添木, 武","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若槻, 哲三","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-31"}],"displaytype":"detail","filename":"k3756_abstract.pdf","filesize":[{"value":"98.4 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2010192/files/k3756_abstract.pdf"},"version_id":"5afb5eb2-e190-411a-a326-50f57df2f0f3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-31"}],"displaytype":"detail","filename":"k3756_review.pdf","filesize":[{"value":"110 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2010192/files/k3756_review.pdf"},"version_id":"0e7fa8a0-c68b-48d7-9cad-60eaef12a3bb"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-31"}],"displaytype":"detail","filename":"k3756_fulltext.pdf","filesize":[{"value":"2.91 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010192/files/k3756_fulltext.pdf"},"version_id":"0cc4db1d-7639-478a-96e2-9625f17cd6d8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Esaxerenone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mineralocorticoid receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aldosterone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-24"},"publish_date":"2022-08-24","publish_status":"0","recid":"2010192","relation_version_is_last":true,"title":["Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T07:50:05.739812+00:00"}