{"created":"2024-12-12T07:51:18.684885+00:00","id":2010208,"links":{},"metadata":{"_buckets":{"deposit":"c066bb2f-1e04-4d44-a79b-e44622e31a10"},"_deposit":{"created_by":7,"id":"2010208","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010208"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010208","sets":["1713853213384:1713853295607"]},"author_link":["798","209","1418","818","943","1005","1542","228","815","1415"],"control_number":"2010208","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"e560","bibliographicPageStart":"e554","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"The Oncologist","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Rash eruptions are a common side-effect of pemetrexed, for which the administration of 8 mg/day of dexamethasone for 3 days from the day preceding pemetrexed administration is recommended. This study aimed to prospectively assess the effectiveness of prophylactic administration of low-dose dexamethasone for pemetrexed-induced rashes.\nMethods: This single-arm, phase II study recruited patients with non-squamous non–small cell lung cancer and malignant pleural mesothelioma scheduled to receive chemotherapy including pemetrexed. Patients received 2 mg of dexamethasone daily from days 2 to 6 after chemotherapy with pemetrexed. The primary endpoint was the 3-week incidence of rash eruptions.\nResults: Twenty-five patients were enrolled between September 2017 and May 2019. The incidence of rash after 3 weeks was 16.7%. Rashes erupted mainly on the upper half of the body, such as the chest and neck, and were of grades 1 and 2 in 2 patients each. No rashes of grade 3 or higher were observed, and there were no adverse events associated with additional corticosteroids.\nConclusion: Prophylactic administration of low-dose dexamethasone for 5 days from the day after pemetrexed administration resulted in a milder incidence and severity of rash. These findings may provide a standard preventative strategy for pemetrexed-induced rashes. (Trial identifier: UMIN000025666).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"1549490X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"10837159","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11157189","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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dexamethasone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pemetrexed","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-squamous non–small cell lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"malignant pleural mesothelioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prevention of Pemetrexed-Induced Rash Using Low-Dose Corticosteroids : A Phase II Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prevention of Pemetrexed-Induced Rash Using Low-Dose Corticosteroids : A Phase II 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