{"created":"2024-12-12T07:54:00.370475+00:00","id":2010240,"links":{},"metadata":{"_buckets":{"deposit":"86631aeb-e006-4f27-898a-c221921b0d3e"},"_deposit":{"created_by":7,"id":"2010240","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010240"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010240","sets":["1713853213384:1713853295607"]},"author_link":["1139"],"control_number":"2010240","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1788","bibliographicPageStart":"1779","bibliographicVolumeNumber":"113","bibliographic_titles":[{"bibliographic_title":"Cancer Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Intraperitoneal administration of anticancer nanoparticles is a rational strategy for preventing peritoneal dissemination of colon cancer due to the prolonged retention of nanoparticles in the abdominal cavity. However, instability of nanoparticles in body fluids causes inefficient retention, reducing its anticancer effects. We have previously developed anticancer nanoparticles containing tocopheryl succinate, which showed high in vivo stability and multifunctional anticancer effects. In the present study, we have demonstrated that peritoneal dissemination derived from colon cancer was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. The biodistribution of tocopheryl succinate nanoparticles was evaluated using inductively coupled plasma mass spectroscopy and imaging analysis in mice administered quantum dot encapsulated tocopheryl succinate nanoparticles. Intraperitoneal administration of tocopheryl succinate nanoparticles showed longer retention in the abdominal cavity than by its intravenous (i.v.) administration. Moreover, due to effective biodistribution, tumor growth was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. Furthermore, the anticancer effect was attributed to the inhibition of cancer cell proliferation and improvement of the intraperitoneal microenvironment, such as decrease in the levels of vascular endothelial growth factor A, interleukin 10, and M2-like phenotype of tumor-associated macrophages. Collectively, intraperitoneal administration of tocopheryl succinate nanoparticles is expected to have multifaceted antitumor effects against colon cancer with peritoneal dissemination.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Cancer Association","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13497006","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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エイタロウ","creatorNameLang":"ja"},{"creatorName":"イソノ, エイタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Isono, Eitaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イタクラ, ショウコ","creatorNameLang":"ja"},{"creatorName":"イタクラ, ショウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Itakura, Shoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシカワ, ユタカ","creatorNameLang":"ja"},{"creatorName":"ヨシカワ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshikawa, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニシモト, アキノリ","creatorNameLang":"ja"},{"creatorName":"ニシモト, アキノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishimoto, Akinori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スズキ, サトコ","creatorNameLang":"ja"},{"creatorName":"スズキ, サトコ","creatorNameLang":"ja-Kana"},{"creatorName":"Suzuki, Satoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キリムラ, ナオコ","creatorNameLang":"ja"},{"creatorName":"キリムラ, ナオコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kirimura, Naoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トウドウ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"トウドウ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Todo, Hiroaki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小暮, 健太朗","creatorNameLang":"ja"},{"creatorName":"コグレ, ケンタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kogure, 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MB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010240/files/cas_113_5_1779.pdf"},"version_id":"08535fe7-b789-4a03-b60a-0da1e477c633"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ascites","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intraperitoneal administration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nanoparticles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peritoneal dissemination","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tocopheryl succinate","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Intraperitoneal administration of nanoparticles containing tocopheryl succinate prevents peritoneal dissemination","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intraperitoneal administration of nanoparticles containing tocopheryl succinate prevents peritoneal dissemination","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-09-08"},"publish_date":"2022-09-08","publish_status":"0","recid":"2010240","relation_version_is_last":true,"title":["Intraperitoneal administration of nanoparticles containing tocopheryl succinate prevents peritoneal dissemination"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-30T07:41:13.581212+00:00"}