{"created":"2024-12-12T07:54:26.814164+00:00","id":2010245,"links":{},"metadata":{"_buckets":{"deposit":"bef8e5a9-5dde-482d-bbf3-ce602abaceb9"},"_deposit":{"created_by":7,"id":"2010245","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010245"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010245","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["761","1180","866","1507","949","1274","1586","1585"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"全トランスレチノイン酸はMAPKシグナル依存的なGADD34の増加を介して筋繊維タイプを変化させる","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Increase of GADD34 expression in skeletal muscle by ATRA","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"e202101345","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Life Science Alliance","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"All-trans retinoic acid (ATRA) increases the sensitivity to unfolded protein response in differentiating leukemic blasts. The downstream transcriptional factor of PERK, a major arm of unfolded protein response, regulates muscle differentiation. However, the role of growth arrest and DNA damage-inducible protein 34 (GADD34), one of the downstream factors of PERK, and the effects of ATRA on GADD34 expression in muscle remain unclear. In this study, we identified ATRA increased the GADD34 expression independent of the PERK signal in the gastrocnemius muscle of mice. ATRA up-regulated GADD34 expression through the transcriptional activation of GADD34 gene via inhibiting the interaction of homeobox Six1 and transcription co-repressor TLE3 with the MEF3-binding site on the GADD34 gene promoter in skeletal muscle. ATRA also inhibited the interaction of TTP, which induces mRNA degradation, with AU-rich element on GADD34 mRNA via p-38 MAPK, resulting in the instability of GADD34 mRNA. Overexpressed GADD34 in C2C12 cells changes the type of myosin heavy chain in myotubes. These results suggest ATRA increases GADD34 expression via transcriptional and post-transcriptional regulation, which changes muscle fiber type.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Life Science Alliance","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"25751077","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3707号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Yuichiro Adachiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科栄養学研究科（医科栄養学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第295号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.26508/lsa.202101345"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.26508/lsa.202101345","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"391703"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"足立, 雄一郎","creatorNameLang":"ja"},{"creatorName":"アダチ, ユウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Adachi, Yuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"増田, 真志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"榊原, 伊織","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内田, 貴之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ニイダ, ユウキ","creatorNameLang":"ja"},{"creatorName":"ニイダ, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Niida, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリ, ユウキ","creatorNameLang":"ja"},{"creatorName":"モリ, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"亀井, 優輝","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"オクムラ, ヨウスケ","creatorNameLang":"ja"},{"creatorName":"オクムラ, ヨウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Okumura, Yosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大南, 博和","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西, 康太","creatorNameLang":"ja"},{"creatorName":"オオニシ, コウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohnishi, Kohta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"(山中)奥村, 仙示","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二川, 健","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹谷, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1585","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3707_abstract_review.pdf","filesize":[{"value":"212 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2010245/files/k3707_abstract_review.pdf"},"version_id":"7f245e09-f339-489e-85dc-3bd8233becfb"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3707_fulltext.pdf","filesize":[{"value":"2.83 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010245/files/k3707_fulltext.pdf"},"version_id":"8eead18d-a6e1-407d-a127-2d2d6c361e9f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MAPK","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mRNA stabilization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"skeletal muscle type change","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transcription","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"unfolded protein response","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-09-06"},"publish_date":"2022-09-06","publish_status":"0","recid":"2010245","relation_version_is_last":true,"title":["All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T07:54:37.685036+00:00"}