{"created":"2024-12-12T07:56:38.667098+00:00","id":2010273,"links":{},"metadata":{"_buckets":{"deposit":"ea815d8b-5691-4393-bfbf-2227912ee667"},"_deposit":{"created_by":7,"id":"2010273","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010273"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010273","sets":["1713853213384:1713853295607"]},"author_link":["306","575"],"control_number":"2010273","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Methylation Analysis in Treatment-Resistant Schizophrenia","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"734606","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Frontiers in Psychiatry","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Schizophrenia is a mental illness that involves both genetic and environmental factors. Clozapine, an atypical antipsychotic, is a well-established therapy for treatment-resistant schizophrenia. In this study, we focused on a set of monozygotic twins with treatment-resistant schizophrenia in which one twin effectively responded to clozapine treatment and the other did not. Our previous study generated neurons from induced pluripotent stem (iPS) cells derived from these patients and compared the transcriptome profiles between mock- and clozapine-treated neurons. In this study, we performed genome-wide DNA methylation profiling to investigate the mechanisms underlying gene expression changes. First, we extracted the differentially methylated sites from each twin based on statistical analysis. Then, we combined the DNA methylation profiling with transcriptome profiling from our previous RNA-seq data. Among the genes with altered methylation and expression, we found the different proportions of the genes related to neuronal and synaptic functions between the clozapine responder and non-responder (35.7 and 6.7%, respectively). This trend was observed even when the basal differences between the responder and non-responder was excluded. These results suggest that effective clozapine action may correct the abnormalities of neuronal and synapse functions in schizophrenia via changes in methylation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"16640640","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3389/fpsyt.2021.734606"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fpsyt.2021.734606","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"387875"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"キクチ, マサタカ","creatorNameLang":"ja"},{"creatorName":"キクチ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kikuchi, Masataka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカザワ, タカノブ","creatorNameLang":"ja"},{"creatorName":"ナカザワ, タカノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakazawa, Takanobu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"木下, 誠","creatorNameLang":"ja"},{"creatorName":"キノシタ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Kinoshita, Makoto","creatorNameLang":"en"}],"familyNames":[{"familyName":"木下","familyNameLang":"ja"},{"familyName":"キノシタ","familyNameLang":"ja-Kana"},{"familyName":"Kinoshita","familyNameLang":"en"}],"givenNames":[{"givenName":"誠","givenNameLang":"ja"},{"givenName":"マコト","givenNameLang":"ja-Kana"},{"givenName":"Makoto","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"575","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40622478","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40622478"}]},{"creatorNames":[{"creatorName":"ヤマモリ, ヒデナガ","creatorNameLang":"ja"},{"creatorName":"ヤマモリ, ヒデナガ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamori, Hidenaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤスダ, ユカ","creatorNameLang":"ja"},{"creatorName":"ヤスダ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuda, Yuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジモト, ミチコ","creatorNameLang":"ja"},{"creatorName":"フジモト, ミチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Michiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja"},{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Ryota","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"沼田, 周助","creatorNameLang":"ja"},{"creatorName":"ヌマタ, シュウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Numata, Shusuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"沼田","familyNameLang":"ja"},{"familyName":"ヌマタ","familyNameLang":"ja-Kana"},{"familyName":"Numata","familyNameLang":"en"}],"givenNames":[{"givenName":"周助","givenNameLang":"ja"},{"givenName":"シュウスケ","givenNameLang":"ja-Kana"},{"givenName":"Shusuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"306","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172447/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172447/profile-ja.html"},{"nameIdentifier":"10403726","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10403726"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-10-28"}],"displaytype":"detail","filename":"fpsyt_12_734606.pdf","filesize":[{"value":"391 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010273/files/fpsyt_12_734606.pdf"},"version_id":"78f23cac-d3a2-4f9d-9377-14a0a11c8537"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"schizophrenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clozapine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA methylation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"monozygotic twins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"iPS cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Methylation Analysis in Monozygotic Twins With Treatment-Resistant Schizophrenia and Discordant Responses to Clozapine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Methylation Analysis in Monozygotic Twins With Treatment-Resistant Schizophrenia and Discordant Responses to Clozapine","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-10-28"},"publish_date":"2022-10-28","publish_status":"0","recid":"2010273","relation_version_is_last":true,"title":["Methylation Analysis in Monozygotic Twins With Treatment-Resistant Schizophrenia and Discordant Responses to Clozapine"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T10:21:46.384798+00:00"}