{"created":"2024-12-12T07:56:52.608003+00:00","id":2010276,"links":{},"metadata":{"_buckets":{"deposit":"73f469ff-4fcf-4777-ade3-f08ee7ba4dde"},"_deposit":{"created_by":7,"id":"2010276","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010276"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010276","sets":["1713853213384:1713853295607"]},"author_link":["1683","1721","813","1339"],"control_number":"2010276","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"3239","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The relationship between autoimmunity and changes in intestinal microbiota is not yet fully understood. In this study, the role of intestinal microbiota in the onset and progression of autoimmune lesions in non-obese diabetic (NOD) mice was evaluated by administering antibiotics to alter their intestinal microenvironment. Flow cytometric analysis of spleen cells showed that antibiotic administration did not change the proportion or number of T and B cells in NOD mice, and pathological analysis demonstrated that autoimmune lesions in the salivary glands and in the pancreas were also not affected by antibiotic administration. These results suggest that the onset and progression of autoimmunity may be independent of enteral microbiota changes. Our findings may be useful for determining the appropriate use of antibiotics in patients with autoimmune diseases who are prescribed drugs to maintain systemic immune function.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/ijms22063239"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms22063239","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"390170"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"サトウ, マミ","creatorNameLang":"ja"},{"creatorName":"サトウ, マミ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Mami","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"新垣, 理恵子","creatorNameLang":"ja"},{"creatorName":"アラカキ, リエコ","creatorNameLang":"ja-Kana"},{"creatorName":"Arakaki, Rieko","creatorNameLang":"en"}],"familyNames":[{"familyName":"新垣","familyNameLang":"ja"},{"familyName":"アラカキ","familyNameLang":"ja-Kana"},{"familyName":"Arakaki","familyNameLang":"en"}],"givenNames":[{"givenName":"理恵子","givenNameLang":"ja"},{"givenName":"リエコ","givenNameLang":"ja-Kana"},{"givenName":"Rieko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1683","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00193061","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00193061"}]},{"creatorNames":[{"creatorName":"俵, 宏彰","creatorNameLang":"ja"},{"creatorName":"タワラ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tawara, Hiroaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"俵","familyNameLang":"ja"},{"familyName":"タワラ","familyNameLang":"ja-Kana"},{"familyName":"Tawara","familyNameLang":"en"}],"givenNames":[{"givenName":"宏彰","givenNameLang":"ja"},{"givenName":"ヒロアキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1339","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"405984/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/405984/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"常松, 貴明","creatorNameLang":"ja"},{"creatorName":"ツネマツ, タカアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsunematsu, Takaaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"常松","familyNameLang":"ja"},{"familyName":"ツネマツ","familyNameLang":"ja-Kana"},{"familyName":"Tsunematsu","familyNameLang":"en"}],"givenNames":[{"givenName":"貴明","givenNameLang":"ja"},{"givenName":"タカアキ","givenNameLang":"ja-Kana"},{"givenName":"Takaaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"813","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"304905/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/304905/profile-ja.html"},{"nameIdentifier":"70726752","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70726752"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"石丸, 直澄","creatorNameLang":"ja"},{"creatorName":"イシマル, ナオズミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishimaru, Naozumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"石丸","familyNameLang":"ja"},{"familyName":"イシマル","familyNameLang":"ja-Kana"},{"familyName":"Ishimaru","familyNameLang":"en"}],"givenNames":[{"givenName":"直澄","givenNameLang":"ja"},{"givenName":"ナオズミ","givenNameLang":"ja-Kana"},{"givenName":"Naozumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1721","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60444/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60444/profile-ja.html"},{"nameIdentifier":"60314879","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60314879"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-10-28"}],"displaytype":"detail","filename":"ijms_22_6_3239.pdf","filesize":[{"value":"2.19 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010276/files/ijms_22_6_3239.pdf"},"version_id":"470d4c14-ef6d-4097-944a-1919466987e7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NOD mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune lesion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sjögren’s syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"type 1 diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antibiotic treatment","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-10-28"},"publish_date":"2022-10-28","publish_status":"0","recid":"2010276","relation_version_is_last":true,"title":["Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:56:35.675506+00:00"}