{"created":"2024-12-12T07:58:30.282894+00:00","id":2010299,"links":{},"metadata":{"_buckets":{"deposit":"d21b2630-d1d3-41c3-b2cb-91ea76dcdd5a"},"_deposit":{"created_by":7,"id":"2010299","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010299"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010299","sets":["1713853213384:1713853295607"]},"author_link":["501","309"],"control_number":"2010299","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Effects of canagliflozin on WBC counts","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1999","bibliographicPageStart":"1990","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Journal of Diabetes Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims/Introduction: Clinical evidence is lacking about the influence of sodium–glucose cotransporter 2 inhibitors on white blood cell (WBC) counts, a commonly used and widely available marker of inflammation. The aim of the present analysis was to assess the effect of canagliflozin relative to glimepiride on WBC counts.\nMaterials and Methods: This was a post-hoc subanalysis of the CANDLE trial (Effects of Canagliflozin in Patients with Type 2 Diabetes and Chronic Heart Failure: A Randomized Trial; UMIN000017669), an investigator-initiated, multicenter, open-label, randomized, controlled trial. A total of 233 patients with type 2 diabetes and concomitant heart failure were randomly assigned to either canagliflozin (n = 113) or glimepiride (n = 120) treatment for 24 weeks. Overall, patient baseline characteristics were as follows: mean ± standard deviation age, 68.6 ± 10.1 years; hemoglobin A1c, 7.0 ± 0.9%; left ventricular ejection fraction, 56.7 ± 14.4%; and median N-terminal pro-brain natriuretic peptide, 252 pg/mL (interquartile range 96–563 pg/mL). The mean baseline WBC counts were 6704 cells/μL (95% confidence interval 6,362–7,047) in the canagliflozin group and 6322 cells/μL (95% confidence interval 5,991–6,654) in the glimepiride group. There were no significant differences between treatment groups in terms of changes in WBC counts from baseline to weeks 4 and 12. In contrast, a group difference (canagliflozin minus glimepiride) from baseline to week 24 was significant (mean difference − 456 cells/μL [95% confidence interval −774 to −139, P = 0.005]).\nConclusions: Our findings suggest that 24 weeks of treatment with canagliflozin, relative to glimepiride, reduced WBC counts in patients with type 2 diabetes and heart failure.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Asian Association for the Study of Diabetes","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20401124","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12488319","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1111/jdi.13899"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/jdi.13899","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"392132"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"タナカ, アツシ","creatorNameLang":"ja"},{"creatorName":"タナカ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イマイ, タクミ","creatorNameLang":"ja"},{"creatorName":"イマイ, タクミ","creatorNameLang":"ja-Kana"},{"creatorName":"Imai, Takumi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"島袋, 充生","creatorNameLang":"ja"},{"creatorName":"シマブクロ, ミチオ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimabukuro, Michio","creatorNameLang":"en"}],"familyNames":[{"familyName":"島袋","familyNameLang":"ja"},{"familyName":"シマブクロ","familyNameLang":"ja-Kana"},{"familyName":"Shimabukuro","familyNameLang":"en"}],"givenNames":[{"givenName":"充生","givenNameLang":"ja"},{"givenName":"ミチオ","givenNameLang":"ja-Kana"},{"givenName":"Michio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"501","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60271144","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60271144"}]},{"creatorNames":[{"creatorName":"ナカムラ, イクコ","creatorNameLang":"ja"},{"creatorName":"ナカムラ, イクコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Ikuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツナガ, カズオ","creatorNameLang":"ja"},{"creatorName":"マツナガ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsunaga, Kazuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オザキ, ユキオ","creatorNameLang":"ja"},{"creatorName":"オザキ, ユキオ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozaki, Yukio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミナミノ, トオル","creatorNameLang":"ja"},{"creatorName":"ミナミノ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Minamino, Tohru","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]},{"creatorNames":[{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja"},{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Node, Koichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-09-22"}],"displaytype":"detail","filename":"jdi_13_12_1990.pdf","filesize":[{"value":"651 KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010299/files/jdi_13_12_1990.pdf"},"version_id":"024b3c2c-6282-47eb-ab4d-80beeba4e3df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chronic heart failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sodium–glucose cotransporter 2 inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"White blood cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of canagliflozin on white blood cell counts in patients with type 2 diabetes and heart failure : A subanalysis of the randomized CANDLE trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of canagliflozin on white blood cell counts in patients with type 2 diabetes and heart failure : A subanalysis of the randomized CANDLE 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