{"created":"2024-12-12T07:58:54.674435+00:00","id":2010305,"links":{},"metadata":{"_buckets":{"deposit":"eeb89227-6c06-415d-8888-ed78a83c8fae"},"_deposit":{"created_by":7,"id":"2010305","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010305"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010305","sets":["1713853213384:1713853295607"]},"author_link":["300"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"DNA adjuvants for potent mucosal immunity","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"205","bibliographicPageStart":"195","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Microbiology and Immunology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to develop safe vaccines for effective mucosal immunity to major pulmonary bacterial infections, one must consider appropriate vaccine antigens (Ags), delivery systems and nontoxic molecular adjuvants. Such vaccine constructs can induce Ag-specific immune responses which provide effective protection from mucosal infections. In particular, it has been shown that adjuvant-based mucosal vaccine preparations are relatively easy to construct by simply mixing the adjuvant with the bacterial Ag, and the resulting vaccine can elicit protective immunity. We have studied DNA-based nasal adjuvants targeting mucosal dendritic cells (DCs) in order to induce Ag-specific mucosal and systemic immune responses that provide essential protection against microbial pathogens which invade our mucosal surfaces. In this review, we initially introduce a plasmid encoding the cDNA of Flt3 ligand (pFL), a molecule which is a growth factor for DCs as an effective adjuvant for mucosal immunity to pneumococcal infections. Next, we discuss the potential of adding unmethylated CpG oligodeoxynucleotide together with pFL together with a pneumococcal Ag for protection from pneumococcal infections. To do this, we have used pneumococcal surface protein A as vaccine for the restoration of mucosal  immunity in aging. Further, we have also used our nasal pFL adjuvant system with phosphorylcholine-keyhole limpet hemocyanin (PC-KLH) in pneumococcal vaccine development, to successfully induce complete protection from nasal carriage by Streptococcus pneumoniae. Finally, we discuss the possibility that anti-PC antibodies induced by nasal delivery of pFL plus PC-KLH may play a protective role for prevention of atherogenesis and thus block the subsequent development of cardiovascular disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society for Bacteriology","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Society for Virology","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Society for Host Defense Research","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: Kataoka, K., Fukuyama, Y., Briles, D.E., Miyake, T. and Fujihashi, K. (2017), Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae. Microbiol Immunol, 61: 195-205., which has been published in final form at https://doi.org/10.1111/1348-0421.12487. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wileyʼs version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13480421","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00738350","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1111/1348-0421.12487"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/1348-0421.12487","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"374192"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"片岡, 宏介","creatorNameLang":"ja"},{"creatorName":"カタオカ, コウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kataoka, Kosuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"片岡","familyNameLang":"ja"},{"familyName":"カタオカ","familyNameLang":"ja-Kana"},{"familyName":"Kataoka","familyNameLang":"en"}],"givenNames":[{"givenName":"宏介","givenNameLang":"ja"},{"givenName":"コウスケ","givenNameLang":"ja-Kana"},{"givenName":"Kosuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"300","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172135/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172135/profile-ja.html"},{"nameIdentifier":"50283792","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50283792"}]},{"creatorNames":[{"creatorName":"フクヤマ, ヨシコ","creatorNameLang":"ja"},{"creatorName":"フクヤマ, ヨシコ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuyama, Yoshiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Briles, David E.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤケ, タツロウ","creatorNameLang":"ja"},{"creatorName":"ミヤケ, タツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyake, Tatsuro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジハシ, コウタロウ","creatorNameLang":"ja"},{"creatorName":"フジハシ, コウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujihashi, Kohtaro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-21"}],"displaytype":"detail","filename":"mi_61_6_195.pdf","filesize":[{"value":"1.23 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010305/files/mi_61_6_195.pdf"},"version_id":"8f6e9240-7793-484a-9730-b83b6f2cb744"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dendritic cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA-based adjuvants","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nasal vaccination","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcus pneumoniae","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-07-21"},"publish_date":"2023-07-21","publish_status":"0","recid":"2010305","relation_version_is_last":true,"title":["Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-27T06:43:59.523871+00:00"}