{"created":"2024-12-12T08:02:37.325955+00:00","id":2010354,"links":{},"metadata":{"_buckets":{"deposit":"1f28a1b9-1dd9-4cd6-a465-7092a7360c3e"},"_deposit":{"created_by":7,"id":"2010354","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010354"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010354","sets":["1713853213384:1713853295607"]},"author_link":["557","220"],"control_number":"2010354","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"22","bibliographicPageStart":"12439","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Conformational conversion of the cellular isoform of prion protein, PrPC, into the abnormally folded, amyloidogenic isoform, PrPSc, is an underlying pathogenic mechanism in prion diseases. The diseases manifest as sporadic, hereditary, and acquired disorders. Etiological mechanisms driving the conversion of PrPC into PrPSc are unknown in sporadic prion diseases, while prion infection and specific mutations in the PrP gene are known to cause the conversion of PrPC into PrPSc in acquired and hereditary prion diseases, respectively. We recently reported that a neurotropic strain of influenza A virus (IAV) induced the conversion of PrPC into PrPSc as well as formation of infectious prions in mouse neuroblastoma cells after infection, suggesting the causative role of the neuronal infection of IAV in sporadic prion diseases. Here, we discuss the conversion mechanism of PrPC into PrPSc in different types of prion diseases, by presenting our findings of the IAV infection-induced conversion of PrPC into PrPSc and by reviewing the so far reported transgenic animal models of hereditary prion diseases and the reverse genetic studies, which have revealed the structure-function relationship for PrPC to convert into PrPSc after prion infection.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/ijms222212439"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms222212439","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"388676"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"原, 英之","creatorNameLang":"ja"},{"creatorName":"ハラ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hara, Hideyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"原","familyNameLang":"ja"},{"familyName":"ハラ","familyNameLang":"ja-Kana"},{"familyName":"Hara","familyNameLang":"en"}],"givenNames":[{"givenName":"英之","givenNameLang":"ja"},{"givenName":"ヒデユキ","givenNameLang":"ja-Kana"},{"givenName":"Hideyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"557","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"246661/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/246661/profile-ja.html"},{"nameIdentifier":"40469953","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40469953"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"坂口, 末廣","creatorNameLang":"ja"},{"creatorName":"サカグチ, スエヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakaguchi, Suehiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"坂口","familyNameLang":"ja"},{"familyName":"サカグチ","familyNameLang":"ja-Kana"},{"familyName":"Sakaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"末廣","givenNameLang":"ja"},{"givenName":"スエヒロ","givenNameLang":"ja-Kana"},{"givenName":"Suehiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"220","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"140706/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/140706/profile-ja.html"},{"nameIdentifier":"60274635","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60274635"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-11-25"}],"displaytype":"detail","filename":"ijms_22_22_12439.pdf","filesize":[{"value":"565 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010354/files/ijms_22_22_12439.pdf"},"version_id":"adbbacde-86ad-48cb-8234-edf26b517d09"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"prion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prion protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prion disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurodegenerative disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"virus infection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"conformational conversion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"influenza virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein polymerization","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-25"},"publish_date":"2022-11-25","publish_status":"0","recid":"2010354","relation_version_is_last":true,"title":["Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T09:51:59.213402+00:00"}