{"created":"2024-12-12T08:03:27.664101+00:00","id":2010364,"links":{},"metadata":{"_buckets":{"deposit":"205c24e4-5fcf-432d-b8ee-68835fa6f5f3"},"_deposit":{"created_by":7,"id":"2010364","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010364"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010364","sets":["1713853213384:1713853295607"]},"author_link":["1198"],"control_number":"2010364","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Influence of insulin injection on skin","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1003","bibliographicPageStart":"997","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Journal of Diabetes Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims/Introduction: The influence of repeated insulin injection on subcutaneous tissue is known, but its impact on the skin is unclear. Therefore, this study aimed to elucidate the impact of repeated insulin injections on the skin.\nMaterial and Methods: The properties of the skin and the subcutaneous tissue were evaluated in 52 insulin-treated adult patients with diabetes with abnormal findings at the site of self-injection (36 with subcutaneous nodules, 16 with suspected subcutaneous tissue induration) by ultrasonography. In all subjects, both normal and abnormal areas were examined. In addition, skin biopsies were performed in four subjects.\nResults: The skin thickness of the normal and abnormal skin sites was 1.95 (1.60, 2.50) and 2.80 (2.27, 3.30) mm, respectively (median (first quartile, third quartile)), (P < 0.001). The biopsy specimens revealed slightly thickened and tight bundles of collagen in the dermis. Three patients had amyloid deposits in the subcutaneous tissue, and one also showed these in the dermis. These were positively stained for insulin antibody.\nConclusions: Repeated insulin injection procedures result in skin thickening. Increased collagen fibers and possibly amyloid deposition in the dermis may be involved. The results reaffirmed the importance of appropriate site rotation in insulin injection and revealed the usefulness of ultrasonographic skin examination in evaluating the self-injection procedure.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Asian Association for the Study of Diabetes","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20401124","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12488319","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1111/jdi.13753"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/jdi.13753","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"388816"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ムラオ, サトシ","creatorNameLang":"ja"},{"creatorName":"ムラオ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Murao, Satoshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"村尾, 和俊","creatorNameLang":"ja"},{"creatorName":"ムラオ, カズトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Murao, Kazutoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"村尾","familyNameLang":"ja"},{"familyName":"ムラオ","familyNameLang":"ja-Kana"},{"familyName":"Murao","familyNameLang":"en"}],"givenNames":[{"givenName":"和俊","givenNameLang":"ja"},{"givenName":"カズトシ","givenNameLang":"ja-Kana"},{"givenName":"Kazutoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1198","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70556/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/70556/profile-ja.html"},{"nameIdentifier":"40363171","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40363171"}]},{"creatorNames":[{"creatorName":"ナガタ, ツヨシ","creatorNameLang":"ja"},{"creatorName":"ナガタ, ツヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagata, Tsuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シミズ, ミサト","creatorNameLang":"ja"},{"creatorName":"シミズ, ミサト","creatorNameLang":"ja-Kana"},{"creatorName":"Shimizu, Misato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤイ, ユミ","creatorNameLang":"ja"},{"creatorName":"ミヤイ, ユミ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyai, Yumi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-12-02"}],"displaytype":"detail","filename":"jdi_13_6_997.pdf","filesize":[{"value":"1.31 MB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010364/files/jdi_13_6_997.pdf"},"version_id":"5d080da1-af3b-4c43-9edc-1794a05e4f80"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amyloidosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipohypertrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Skin thickness","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Repeated insulin injection without site rotation affects skin thickness : ultrasonographic and histological evaluation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Repeated insulin injection without site rotation affects skin thickness : ultrasonographic and histological evaluation","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-02"},"publish_date":"2022-12-02","publish_status":"0","recid":"2010364","relation_version_is_last":true,"title":["Repeated insulin injection without site rotation affects skin thickness : ultrasonographic and histological evaluation"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:02:29.146052+00:00"}