{"created":"2024-12-12T08:07:58.146421+00:00","id":2010417,"links":{},"metadata":{"_buckets":{"deposit":"67b3fd3c-3c29-4941-bd43-33ff2d208070"},"_deposit":{"created_by":7,"id":"2010417","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010417"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010417","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["852","349","710","781","936","175","1572","756","287"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"鋸歯状ポリポーシス症候群におけるadenoma-carcinoma pathwayによる発癌","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Adenoma-cancer pathway in SPS","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"299","bibliographicPageStart":"286","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Journal of Gastroenterology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Although serrated polyposis syndrome (SPS) is associated with an increased colorectal cancer (CRC) risk, the carcinogenic mechanisms remain unknown. We investigated clinicopathological characteristics and genetic abnormalities in colorectal polyps and CRC to elucidate carcinogenic mechanisms in SPS.\nMethods: We retrospectively analyzed clinicopathological features of colorectal polyps in 44 SPS patients, and examined mutations of genes including APC, RAS, BRAF, and TP53, and microsatellite instability (MSI) in CRC tissues.\nResults: Of the 44 patients, 25 (56%) fulfilled WHO criterion 1, 11 (25%) fulfilled criterion 2, and 8 (18%) fulfilled both. A total of 956 polyps were observed; 642 (67%) hyperplastic polyps (HP), 204 (21%) sessile serrated lesions (SSL), 10 (1%) traditional serrated adenoma (TSA), and 100 (11%) adenomas. The median numbers of polyps (/patient) were 10.5 (IQR 2.75-23) HPs, 4.0 (2.0-6.0) SSLs, 0 (0-0) TSA, and 1 (0-3.3) adenoma. SSL and HP located preferentially in the proximal and distal colon respectively. Twenty-two CRCs were found in 18 patients. Based on the histological coexistence of SSL/TSA, BRAF mutation and MSI, 5 CRCs (26%) were classified as serrated-neoplasia pathway. Conversely, based on the coexistence of adenoma, APC/RAS and TP53 mutations, 11 CRCs (58%) were classified as adenoma-carcinoma pathway. The remaining 3 were unclassifiable. Most CRCs through adenoma-carcinoma pathway were located in the left-side colorectum and patients bearing those met criterion 2, characterized by many HP and advanced adenomas. Adenoma was a significant risk factor for CRC.\nConclusions: Our results suggest that more than half of the CRCs, particularly those in the left-side colorectum, developed through the adenoma-carcinoma pathway in SPS patients. Adenoma was a risk factor for CRCs, suggesting its importance in colorectal carcinogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Society of Gastroenterology","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14355922","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"09441174","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11627089","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA10988015","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3659号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-09-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Fumika Nakamuraの学位論文として提出され，学位審査・授与の対象となっている。\nThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Natureʼs AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00535-022-01858-8\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1541号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s00535-022-01858-8"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00535-022-01858-8","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"385400"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 文香","creatorNameLang":"ja"},{"creatorName":"ナカムラ, フミカ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Fumika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 康史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡本, 耕一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤野, 泰輝","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三井, 康裕","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カゲモト, カイゾウ","creatorNameLang":"ja"},{"creatorName":"カゲモト, カイゾウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagemoto, Kaizo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"川口, 智之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本, 弘志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"六車, 直樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ソノダ, トモコ","creatorNameLang":"ja"},{"creatorName":"ソノダ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sonoda, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"常山, 幸一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高山, 哲治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"287","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-10-31"}],"displaytype":"detail","filename":"k3659_abstract.pdf","filesize":[{"value":"115 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2010417/files/k3659_abstract.pdf"},"version_id":"43fc227b-09d8-4ade-89bb-352191edeb25"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-10-31"}],"displaytype":"detail","filename":"k3659_review.pdf","filesize":[{"value":"120 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2010417/files/k3659_review.pdf"},"version_id":"27cb2424-4d70-4dc6-be94-3933b52547f7"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-02-24"}],"displaytype":"detail","filename":"k3659_fulltext.pdf","filesize":[{"value":"2.19 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010417/files/k3659_fulltext.pdf"},"version_id":"76a86912-7732-42f2-a862-a90cedb930f5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"serrated polyposis syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adenoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sessile serrated lesion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adenoma–carcinoma pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serrated-neoplasia pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Colorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Colorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-10-31"},"publish_date":"2022-10-31","publish_status":"0","recid":"2010417","relation_version_is_last":true,"title":["Colorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T08:08:08.345315+00:00"}