{"created":"2024-12-12T08:13:47.879126+00:00","id":2010499,"links":{},"metadata":{"_buckets":{"deposit":"7e00066e-adcd-4125-8d63-246634506c99"},"_deposit":{"created_by":7,"id":"2010499","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010499"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010499","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["837","1185","545","383","381","671","1217","897"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"卵巣摘出ラットにおけるERαおよびSirt1の減少に伴うNLRP3/IL-1β/MMP-9経路の活性化と脳動脈瘤破裂の関連","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"198","bibliographicPageStart":"191","bibliographicVolumeNumber":"138","bibliographic_titles":[{"bibliographic_title":"Journal of Neurosurgery","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"OBJECTIVE\nSubarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is often a devastating event. Since the incidence of SAH increases especially in menopause, it is crucial to clarify the detailed pathogenesis of these events. The activation of vascular nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes has been studied in ischemic stroke and cardiovascular disease. However, the role of NLRP3 in IA rupture still needs to be explained. The authors sought to test their hypothesis that, under estrogen-deficient conditions, activation of NLRP3 inflammasomes via downregulation of the estrogen receptor (ER) facilitates IA rupture.\nMETHODS\nTen-week-old female Sprague Dawley rats with and without oophorectomy were subjected to hemodynamic changes and hypertension (OVX+/HT and OVX-/HT, respectively) and fed a high-salt diet. Separately, using human brain endothelial cells (HBECs) and human brain smooth muscle cells (HBSMCs), the authors tested the effect of NLRP3 under estrogen-free conditions and in the presence of estradiol or of ER agonists.\nRESULTS\nIn OVX+/HT rats, the frequency of IA rupture was significantly higher than in OVX-/HT rats (p = 0.03). In the left posterior cerebral artery prone to rupture in OVX+/HT rats, the levels of the mRNAs encoding ERα and Sirt1, but not of that encoding ERβ, were decreased, and the levels of the mRNAs encoding NLRP3, interleukin-1β (IL-1β), and matrix metalloproteinase 9(MMP-9) were elevated. Immunohistochemical analysis demonstrated that the expression profiles of these proteins correlated with their mRNA levels. Treatment with an ER modulator, bazedoxifene, normalized the expression profiles of these proteins and improved SAH-free survival. In HBECs and HBSMCs under estrogen-free conditions, the depletion of ERα and Sirt1 and the accumulation of NLRP3 were counteracted by exposure to estradiol or to an ERα agonist but not to an ERβ agonist.\nCONCLUSIONS\nTo the authors’ knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association of Neurological Surgeons","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00223085","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"19330693","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00703389","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3665号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-10-27"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Tadashi Yamaguchiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1547号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3171/2022.4.JNS212945"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3171/2022.4.JNS212945","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"385757"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山口, 真司","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi, Tadashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宮本, 健志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"シカタ, エイジ","creatorNameLang":"ja"},{"creatorName":"シカタ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Shikata, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山口, 泉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 健司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"八木, 謙次","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"多田, 恵曜","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高麗, 雅章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"キタザト, ケイコ","creatorNameLang":"ja"},{"creatorName":"キタザト, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitazato, Keiko T.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"兼松, 康久","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1217","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙木, 康志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"897","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-11-14"}],"displaytype":"detail","filename":"k3665_abstract.pdf","filesize":[{"value":"132 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2010499/files/k3665_abstract.pdf"},"version_id":"f9c16295-522e-4980-8973-a08d9ae88231"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-11-14"}],"displaytype":"detail","filename":"k3665_review.pdf","filesize":[{"value":"112 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2010499/files/k3665_review.pdf"},"version_id":"b7b57ddd-eb12-4727-b520-fcc31d6b0275"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-11-14"}],"displaytype":"detail","filename":"k3665_fulltext.pdf","filesize":[{"value":"7.92 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010499/files/k3665_fulltext.pdf"},"version_id":"d485a0a0-3747-4e07-8de2-1e147a3f736a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Estrogen deficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"estrogen receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intracranial aneurysm","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NLRP3 inflammasome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sirt1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular disorders","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-14"},"publish_date":"2022-11-14","publish_status":"0","recid":"2010499","relation_version_is_last":true,"title":["Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T08:13:57.122493+00:00"}