{"created":"2024-12-12T08:14:32.823644+00:00","id":2010509,"links":{},"metadata":{"_buckets":{"deposit":"c9315531-c968-4576-93f5-3c139e9f0db1"},"_deposit":{"created_by":7,"id":"2010509","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010509"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010509","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["708","1469","955","1452","609","1524","439"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"新規PCOSラットモデルの作製とその生殖・代謝・行動表現型の評価","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"e12416","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Reproductive Medicine and Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Although animal models of PCOS have been used in many studies, none of them can reproduce both the reproductive and metabolic phenotypes of PCOS. In addition, behavioral parameters have not been evaluated in PCOS animal models.\nPurpose: We tried to produce an improved rat model of PCOS, and the reproductive, metabolic, and behavioral phenotypes of the model rats were evaluated.\nMethods: Female rats were implanted with silicon tubes containing oil-dissolved dihydrotestosterone (Oil-DHT) as a new PCOS model. Their phenotypes were compared with those of conventional PCOS model rats (DHT), into which tubes containing crystalline DHT were implanted, and non-DHT-treated rats (control).\nResults: Both the Oil-DHT and DHT rats showed greater body weight gain, food intake, and fat depot weight than the control rats. Furthermore, these groups showed fewer estrous stages and increased numbers of cystic follicles. The DHT rats exhibited lower ovarian and uterine weights than the control rats, whereas no such changes were observed in the Oil-DHT rats. The Oil-DHT and DHT rats showed less locomotor activity in the light phase than the control rats.\nConclusions: Our proposed PCOS model reproduced both the reproductive and metabolic phenotypes of PCOS and may have potential for PCOS research.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Society for Reproductive Medicine","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14470578","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11706516","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3796号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は,著者Shuhei Kamadaの学位論文として提出され,学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科(医学専攻)"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1602号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/rmb2.12416"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/rmb2.12416","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"387545"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鎌田, 周平","creatorNameLang":"ja"},{"creatorName":"カマダ, シュウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamada, Shuhei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 由理","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"アオキ, ヒデノリ","creatorNameLang":"ja"},{"creatorName":"アオキ, ヒデノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Aoki, Hidenori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タムラ, コウ","creatorNameLang":"ja"},{"creatorName":"タムラ, コウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamura, Kou","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケダ, アスカ","creatorNameLang":"ja"},{"creatorName":"タケダ, アスカ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeda, Asuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"湊, 沙希","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"マサキ, リエ","creatorNameLang":"ja"},{"creatorName":"マサキ, リエ","creatorNameLang":"ja-Kana"},{"creatorName":"Masaki, Rie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤナギハラ, リエ","creatorNameLang":"ja"},{"creatorName":"ヤナギハラ, リエ","creatorNameLang":"ja-Kana"},{"creatorName":"Yanagihara, Rie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハヤシ, ノリコ","creatorNameLang":"ja"},{"creatorName":"ハヤシ, ノリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤノ, ユウヤ","creatorNameLang":"ja"},{"creatorName":"ヤノ, ユウヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yano, Yuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"今泉, 絢貴","creatorNameLang":"ja"},{"creatorName":"イマイズミ, ジュンキ","creatorNameLang":"ja-Kana"},{"creatorName":"Imaizumi, Junki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"香川, 智洋","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, あつ子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河北, 貴子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"苛原, 稔","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩佐, 武","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"439","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-22"}],"displaytype":"detail","filename":"k3796_abstract.pdf","filesize":[{"value":"156 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2010509/files/k3796_abstract.pdf"},"version_id":"c214118e-c239-46c7-a198-3d15c044669d"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-22"}],"displaytype":"detail","filename":"k3796_review.pdf","filesize":[{"value":"115 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2010509/files/k3796_review.pdf"},"version_id":"02469d1f-6f66-4a1e-b425-536c55074d93"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-22"}],"displaytype":"detail","filename":"k3796_fulltext.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010509/files/k3796_fulltext.pdf"},"version_id":"b4062dcf-b23a-46fa-8143-450a7ec940ec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DHT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PCOS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reproduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-26"},"publish_date":"2022-12-26","publish_status":"0","recid":"2010509","relation_version_is_last":true,"title":["A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T08:14:41.925245+00:00"}