{"created":"2024-12-12T08:16:15.110206+00:00","id":2010531,"links":{},"metadata":{"_buckets":{"deposit":"09655e4d-5729-45fd-a83d-75d2253139a2"},"_deposit":{"created_by":7,"id":"2010531","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010531"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010531","sets":["1713853213384:1713853295607"]},"author_link":["1678","622","1705","1423"],"control_number":"2010531","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"2922","bibliographicPageStart":"2915","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Current Issues in Molecular Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"6-(Methylsulfinyl) hexyl isothiocyanate (6-MSITC) is a bioactive substance found in wasabi (Wasabia japonica) and has been reported to have some bioactive effects including anticancer and antioxidant effects. However, there are no reports on its effects on periodontal resident cells, and many points remain unclear. In this study, we aimed to investigate whether 6-MSITC exerts anti-inflammatory effects on human oral epithelial cells, including effects on signal transduction pathway activation. 6-MSITC inhibited interleukin (IL)-6 and C-X-C motif chemokine ligand 10 (CXCL10) production in TNF-α-stimulated TR146 cells, which are a human oral epithelial cell line. Moreover, we found that 6-MSITC could suppress signal transducer and activator of transcription (STAT)3, nuclear factor (NF)-κB, and p70S6 kinase (p70S6K)-S6 ribosomal protein (S6) pathways activation in TNF-α-stimulated TR146 cells. Furthermore, STAT3 and NF-κB inhibitors could suppress IL-6 and CXCL10 production in TNF-α-treated TR146 cells. In summary, 6-MSITC could decrease IL-6 and CXCL10 production in human oral epithelial cell by inhibiting STAT3 and NF-κB activation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14673045","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/cimb44070201"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/cimb44070201","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"391957"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"シモヤマ, マサヒロ","creatorNameLang":"ja"},{"creatorName":"シモヤマ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimoyama, Masahiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"細川, 義隆","creatorNameLang":"ja"},{"creatorName":"ホソカワ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hosokawa, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"細川","familyNameLang":"ja"},{"familyName":"ホソカワ","familyNameLang":"ja-Kana"},{"familyName":"Hosokawa","familyNameLang":"en"}],"givenNames":[{"givenName":"義隆","givenNameLang":"ja"},{"givenName":"ヨシタカ","givenNameLang":"ja-Kana"},{"givenName":"Yoshitaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1678","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60360/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60360/profile-ja.html"},{"nameIdentifier":"90346601","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90346601"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"細川, 育子","creatorNameLang":"ja"},{"creatorName":"ホソカワ, イクコ","creatorNameLang":"ja-Kana"},{"creatorName":"Hosokawa, Ikuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"細川","familyNameLang":"ja"},{"familyName":"ホソカワ","familyNameLang":"ja-Kana"},{"familyName":"Hosokawa","familyNameLang":"en"}],"givenNames":[{"givenName":"育子","givenNameLang":"ja"},{"givenName":"イクコ","givenNameLang":"ja-Kana"},{"givenName":"Ikuko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"622","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"261400/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/261400/profile-ja.html"},{"nameIdentifier":"50707908","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50707908"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"尾崎, 和美","creatorNameLang":"ja"},{"creatorName":"オザキ, カズミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozaki, Kazumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"尾崎","familyNameLang":"ja"},{"familyName":"オザキ","familyNameLang":"ja-Kana"},{"familyName":"Ozaki","familyNameLang":"en"}],"givenNames":[{"givenName":"和美","givenNameLang":"ja"},{"givenName":"カズミ","givenNameLang":"ja-Kana"},{"givenName":"Kazumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1705","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60420/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60420/profile-ja.html"},{"nameIdentifier":"90214121","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90214121"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"保坂, 啓一","creatorNameLang":"ja"},{"creatorName":"ホサカ, ケイイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Hosaka, Keiichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"保坂","familyNameLang":"ja"},{"familyName":"ホサカ","familyNameLang":"ja-Kana"},{"familyName":"Hosaka","familyNameLang":"en"}],"givenNames":[{"givenName":"啓一","givenNameLang":"ja"},{"givenName":"ケイイチ","givenNameLang":"ja-Kana"},{"givenName":"Keiichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1423","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"374726/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/374726/profile-ja.html"},{"nameIdentifier":"80451946","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80451946"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-01-26"}],"displaytype":"detail","filename":"cimb_44_7_2915.pdf","filesize":[{"value":"1.45 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010531/files/cimb_44_7_2915.pdf"},"version_id":"8f394d7a-baf0-4b15-b8d5-eaabb07ca551"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"6-MSITC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-inflammatory effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oral epithelial cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-26"},"publish_date":"2023-01-26","publish_status":"0","recid":"2010531","relation_version_is_last":true,"title":["6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T06:41:54.836674+00:00"}