{"created":"2024-12-12T08:16:32.864210+00:00","id":2010535,"links":{},"metadata":{"_buckets":{"deposit":"f7959bab-6de4-46e5-9a28-906fdec6ec1e"},"_deposit":{"created_by":7,"id":"2010535","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010535"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010535","sets":["1713853213384:1713853295607"]},"author_link":["1488","877","833","518","1514","1224","737","1634","230"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Treatment algorithm of ACTH deficiency","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"293","bibliographicPageStart":"287","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective : To examine diagnostic performance of corticotropin-releasing hormone (CRH) test combined with baseline dehydroepiandrosterone sulfate (DHEA-S) in patients with a suspect of central adrenal insufficiency. Methods : Patients (n=215) requiring daily or intermittent hydrocortisone replacement, or no replacement were retrospectively checked with their peak cortisol after CRH test and baseline DHEA-S. Results : None of 106 patients with the peak cortisol ≥ 17.5 μg / dL after CRH test required replacement, and all 64 patients with the peak cortisol < 10.0 μg / dL required daily replacement. Among 8 patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL and baseline DHEA-S below the reference range, 6 patients required daily replacement and 1 patient was under intermittent replacement. Among 37 patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL and baseline DHEA-S within the reference range, 10 and 6 patients were under intermittent and daily replacement, respectively. Conclusions : No patients with the peak cortisol ≥ 17.5 μg / dL required hydrocortisone replacement, and all patients with the peak cortisol below 10.0 μg / dL required daily replacement. Careful clinical evaluation was required to determine requirement for replacement in patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL even in combination with baseline DHEA-S.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokushima University Faculty of Medicine","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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トモアキ","creatorNameLang":"ja"},{"creatorName":"タナカ, トモアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Tomoaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"原, 倫世","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"マスダ, シホ","creatorNameLang":"ja"},{"creatorName":"マスダ, シホ","creatorNameLang":"ja-Kana"},{"creatorName":"Masuda, Shiho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオニシ, ユキヨ","creatorNameLang":"ja"},{"creatorName":"オオニシ, ユキヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohnishi, Yukiyo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"金井, 麻衣","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"倉橋, 清衛","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 守美子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"近藤, 剛史","creatorNameLang":"ja"},{"creatorName":"コンドウ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カネザキ, トシコ","creatorNameLang":"ja"},{"creatorName":"カネザキ, トシコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanezaki, Toshiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シンタニ, ヤスミ","creatorNameLang":"ja"},{"creatorName":"シンタニ, ヤスミ","creatorNameLang":"ja-Kana"},{"creatorName":"Shintani, Yasumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山上, 紘規","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヤマグチ, ユウキ","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi, 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正博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤, 逸朗","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"230","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-11-21"}],"displaytype":"detail","filename":"jmi_69_3-4_287.pdf","filesize":[{"value":"851 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010535/files/jmi_69_3-4_287.pdf"},"version_id":"a27edcb7-f07d-47c3-9db2-8a8477c3df6a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"central adrenal insufficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"corticotropin-releasing hormone (CRH) test","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dehydroepiandrosterone-sulfate (DHEA-S)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"retrospective cohort study","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"treatment algorithm","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"An attempt to create a treatment algorithm of central adrenal insufficiency using CRH test, DHEA-S and clinical evaluation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"An attempt to create a treatment algorithm of central adrenal insufficiency using CRH test, DHEA-S and 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