{"created":"2024-12-12T08:17:14.295006+00:00","id":2010543,"links":{},"metadata":{"_buckets":{"deposit":"fab030da-1562-47a2-b281-75a87aeadf58"},"_deposit":{"created_by":7,"id":"2010543","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010543"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010543","sets":["1713853213384:1713853295607"]},"author_link":["959"],"control_number":"2010543","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"2202","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Molecules","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2-O-α-D-Glucopyranosyl-L-ascorbic acid (AA-2G) is one of the stable ascorbic acid (AA) derivatives known as provitamin C agents. We have previously synthesized two types of monoacylated derivatives of AA-2G, 6-O-acyl-2-O-α-D-glucopyranosyl-L-ascorbic acids having a straight-acyl chain of varying length from C4 to C18 (6-sAcyl-AA-2G) and a branched-acyl chain of varying length from C6 to C16 (6-bAcyl-AA-2G) in order to improve the bioavailability of AA-2G. In this study, 6-sAcyl-AA-2G and 6-bAcyl-AA-2G per se showed the inhibitory effects on hyaluronidase activity and degranulation. 6-sAcyl-AA-2G exhibited strong inhibitory effects on hyaluronidase activity and degranulation in a concentration-dependent manner, and the inhibitory effects tended to become stronger with increasing length of the acyl chain. 2-O-α-D-Glucopyranosyl-6-O-hexadecanoyl-L-ascorbic acid (6-sPalm-AA-2G), which has a straight C16 acyl chain, was the most potent effective for inhibition of hyaluronidase activity and for inhibition of degranulation among the 6-sAcyl-AA-2G derivatives and the two isomers of 6-sPalm-AA-2G. Furthermore, percutaneous administration of 6-sPalm-AA-2G significantly inhibited IgE-mediated passive cutaneous anaphylaxis reaction in mice. These findings suggest that 6-sPalm-AA-2G will be useful for treatment of allergies.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14203049","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/molecules22122202"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/molecules22122202","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"359257"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ミウラ, カオリ","creatorNameLang":"ja"},{"creatorName":"ミウラ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Kaori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリシタ, ユウタ","creatorNameLang":"ja"},{"creatorName":"モリシタ, ユウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Morishita, Yuta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツノ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"マツノ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuno, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アオタ, ユウスケ","creatorNameLang":"ja"},{"creatorName":"アオタ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Aota, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, ヒデユキ","creatorNameLang":"ja"},{"creatorName":"イトウ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Hideyuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"田井, 章博","creatorNameLang":"ja"},{"creatorName":"タイ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Tai, Akihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"田井","familyNameLang":"ja"},{"familyName":"タイ","familyNameLang":"ja-Kana"},{"familyName":"Tai","familyNameLang":"en"}],"givenNames":[{"givenName":"章博","givenNameLang":"ja"},{"givenName":"アキヒロ","givenNameLang":"ja-Kana"},{"givenName":"Akihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"959","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"350199/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/350199/profile-ja.html"},{"nameIdentifier":"70284081","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70284081"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-02-07"}],"displaytype":"detail","filename":"molecules_22_12_2202.pdf","filesize":[{"value":"815 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010543/files/molecules_22_12_2202.pdf"},"version_id":"77e46bb4-71da-4c7a-bb79-d5ff7b19a71d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ascorbic acid derivatives","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-allergic activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"degranulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hyaluronidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"passive cutaneous anaphylaxis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-07"},"publish_date":"2023-02-07","publish_status":"0","recid":"2010543","relation_version_is_last":true,"title":["Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T04:39:55.035128+00:00"}