{"created":"2024-12-12T08:21:33.933783+00:00","id":2010599,"links":{},"metadata":{"_buckets":{"deposit":"4af66888-6e7c-44a6-ba21-2ce91700b5b5"},"_deposit":{"created_by":7,"id":"2010599","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010599"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010599","sets":["1713853213384:1713853295607"]},"author_link":["309"],"control_number":"2010599","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"1656","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Biomedicines","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: We present results of a 24-week comparative study of the effects of the sodium–glucose cotransporter 2 (SGLT2) inhibitor canagliflozin vs. the sulfonylurea glimepiride, by baseline body mass index (BMI), in patients with type 2 diabetes and chronic heart failure. Methods: We conducted a post hoc analysis of the CANDLE trial. This subanalysis evaluated NT-proBNP, BMI, and other laboratory parameters, according to the subgroups stratified by BMI ≥ 25 kg/m2 vs. BMI < 25 kg/m2. Results: A group ratio of proportional changes in the geometric means of NT-proBNP was 0.99 (p = 0.940) for the subgroup with BMI ≥ 25 kg/m2 and 0.85 (p = 0.075) for the subgroup with BMI < 25 kg/m2, respectively. When baseline BMI was modeled as a continuous variable, results for patients with BMI < 30 kg/m2 showed a slightly smaller increase in NT-proBNP in the canagliflozin group vs. the glimepiride group (p = 0.295); that difference was not seen among patients with BMI ≥30 kg/m2 (p = 0.948). Irrespective of obesity, the canagliflozin group was associated with significant reduction in BMI compared to the glimepiride group. Conclusion: There was no significant difference in the effects of canagliflozin, relative to glimepiride, on NT-proBNP concentrations irrespective of baseline obesity. UMIN clinical trial registration number: UMIN000017669.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"22279059","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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タクミ","creatorNameLang":"ja"},{"creatorName":"イマイ, タクミ","creatorNameLang":"ja-Kana"},{"creatorName":"Imai, Takumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キダ, ケイスケ","creatorNameLang":"ja"},{"creatorName":"キダ, ケイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kida, Keisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"セキノ, ヒサクニ","creatorNameLang":"ja"},{"creatorName":"セキノ, ヒサクニ","creatorNameLang":"ja-Kana"},{"creatorName":"Sekino, Hisakuni","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムロハラ, トヨアキ","creatorNameLang":"ja"},{"creatorName":"ムロハラ, トヨアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Murohara, Toyoaki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]},{"creatorNames":[{"creatorName":"スズキ, ノリオ","creatorNameLang":"ja"},{"creatorName":"スズキ, ノリオ","creatorNameLang":"ja-Kana"},{"creatorName":"Suzuki, Norio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja"},{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Node, Koichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-01-31"}],"displaytype":"detail","filename":"biomed_10_7_1656.pdf","filesize":[{"value":"1.19 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010599/files/biomed_10_7_1656.pdf"},"version_id":"f4a175eb-cc93-47cd-9b88-95f6ba5d4325"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sodium–glucose transporter 2 inhibitors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"heart failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NT-proBNP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BMI","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparing the Effects of Canagliflozin vs. Glimepiride by Body Mass Index in Patients with Type 2 Diabetes and Chronic Heart Failure : A Subanalysis of the CANDLE Trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparing the Effects of Canagliflozin vs. Glimepiride by Body Mass Index in Patients with Type 2 Diabetes and Chronic Heart Failure : A Subanalysis of the CANDLE Trial","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-31"},"publish_date":"2023-01-31","publish_status":"0","recid":"2010599","relation_version_is_last":true,"title":["Comparing the Effects of Canagliflozin vs. Glimepiride by Body Mass Index in Patients with Type 2 Diabetes and Chronic Heart Failure : A Subanalysis of the CANDLE Trial"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:58:48.167394+00:00"}