{"created":"2024-12-12T09:00:20.921129+00:00","id":2010600,"links":{},"metadata":{"_buckets":{"deposit":"47c6fec6-3f2e-4364-868c-23c0876ca850"},"_deposit":{"created_by":7,"id":"2010600","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010600"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010600","sets":["1713853213384:1713853295607"]},"author_link":["626","1543"],"control_number":"2010600","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-08-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"811","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"BMC Musculoskeletal Disorders","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Severe frozen shoulder (FS) is often resistant to treatment and can thus result in long-term functional impairment. However, its etiology remains unknown. We hypothesized that gene expression of FS would vary by synovial location.\nMethods: The synovial tissues of patients with FS were collected prospectively and analyzed for the expression of 19 genes. Synovial tissues from patients with rotator cuff tear (RCT) or shoulder instability (SI) were also analyzed as controls. A total of 10 samples were analyzed from each group. The specimens were arthroscopically taken from three different locations: rotator interval (RI), axillary recess (AX), and subacromial bursa (SAB). Total RNA was extracted from the collected tissues and was analyzed by real-time polymerase chain reaction for the following genes: matrix metalloproteinases (MMPs); tissue inhibitors of metalloproteinases (TIMPs); inflammatory cytokines (IL1B, TNF, and IL6); type I and II procollagen (COL1A1 and COL2A1); growth factors (IGF1 and TGFB1); neural factors (NGF and NGFR); SOX9; and ACTA2.\nResults: Site-specific analysis showed that MMP13, IL-6, SOX9, and COL1A1 were increased in all three sites. Four genes (MMP3, MMP9, COL2A1, and NGFR) were increased in the AX, MMP3 in the RI, and NGFR in the SAB were increased in the FS group than in the RCT and SI groups. In the FS group, there was a correlation between the expression of genes related to chondrogenesis (MMP2, IGF1, SOX9, COL2A1, NGF, and NGFR) or fibrosis (MMP9, TGFB1, and COL1A1).\nConclusion: The expression levels of numerous MMPs, pro-inflammatory cytokines, and collagen-related genes were increased in the FS group, suggesting that catabolic and anabolic changes have simultaneously occurred. In addition, genes related to chondrogenesis or fibrosis were highly expressed in the FS group, which might have affected the range of motion limitation of the shoulder. Compared to RI and SAB, the AX was the most common site of increased expression in FS. Analyzing the lower region of the shoulder joint may lead to the elucidation of the pathogenesis of FS.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14712474","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12035278","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s12891-022-05762-3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12891-022-05762-3","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"391232"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ニシモト, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"ニシモト, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishimoto, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"福田, 昇司","creatorNameLang":"ja"},{"creatorName":"フクタ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuta, Shoji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フクイ, ナオシ","creatorNameLang":"ja"},{"creatorName":"フクイ, ナオシ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukui, Naoshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西良, 浩一","creatorNameLang":"ja"},{"creatorName":"サイリョウ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Sairyo, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"西良","familyNameLang":"ja"},{"familyName":"サイリョウ","familyNameLang":"ja-Kana"},{"familyName":"Sairyo","familyNameLang":"en"}],"givenNames":[{"givenName":"浩一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1543","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60063/profile-ja.html","nameIdentifierScheme":"徳島大学 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Tetsuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"山口","familyNameLang":"ja"},{"familyName":"ヤマグチ","familyNameLang":"ja-Kana"},{"familyName":"Yamaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"鉄生","givenNameLang":"ja"},{"givenName":"テツオ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"626","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"261430/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/261430/profile-ja.html"},{"nameIdentifier":"80569731","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80569731"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-01-31"}],"displaytype":"detail","filename":"bmcmd_23_811.pdf","filesize":[{"value":"1.55 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010600/files/bmcmd_23_811.pdf"},"version_id":"a3c3493a-252a-42c1-8baa-ec4d7028de16"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Frozen shoulder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chondrogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Characteristics of gene expression in frozen shoulder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characteristics of gene expression in frozen shoulder","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-31"},"publish_date":"2023-01-31","publish_status":"0","recid":"2010600","relation_version_is_last":true,"title":["Characteristics of gene expression in frozen shoulder"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T07:07:58.551017+00:00"}