{"created":"2024-12-12T09:04:37.833895+00:00","id":2010642,"links":{},"metadata":{"_buckets":{"deposit":"d8f78384-37cd-4fbe-a55c-0b9cc50743e7"},"_deposit":{"created_by":7,"id":"2010642","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010642"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010642","sets":["1713853213384:1713853295607"]},"author_link":["239"],"control_number":"2010642","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-08-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"782","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Membranes","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The development of novel effective antibacterial agents is crucial due to increasing antibiotic resistance in various bacteria. Poly (alkyl cyanoacrylate) nanoparticles (PACA-NPs) are promising novel antibacterial agents as they have shown antibacterial activity against several Gram-positive and Gram-negative bacteria. However, the antibacterial mechanism remains unclear. Here, we compared the antibacterial efficacy of ethyl cyanoacrylate nanoparticles (ECA-NPs), isobutyl cyanoacrylate NPs (iBCA-NPs), and ethoxyethyl cyanoacrylate NPs (EECA-NPs) using five Gram-positive and five Gram-negative bacteria. Among these resin nanoparticles, ECA-NPs showed the highest growth inhibitory effect against all the examined bacterial species, and this effect was higher against Gram-positive bacteria than Gram-negative. While iBCA-NP could inhibit the cell growth only in two Gram-positive bacteria, i.e., Bacillus subtilis and Staphylococcus aureus, it had negligible inhibitory effect against all five Gram-negative bacteria examined. Irrespective of the differences in growth inhibition induced by these three NPs, N-acetyl-L-cysteine (NAC), a well-known reactive oxygen species (ROS) scavenger, efficiently restored growth in all the bacterial strains to that similar to untreated cells. This strongly suggests that the exposure to NPs generates ROS, which mainly induces cell growth inhibition irrespective of the difference in bacterial species and cyanoacrylate NPs used.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20770375","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/membranes12080782"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/membranes12080782","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"389314"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sarian, Fean Davisunjaya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アンドウ, カズキ","creatorNameLang":"ja"},{"creatorName":"アンドウ, カズキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ando, Kazuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツルミ, ショウタ","creatorNameLang":"ja"},{"creatorName":"ツルミ, ショウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsurumi, Shota","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤシタ, リョウヘイ","creatorNameLang":"ja"},{"creatorName":"ミヤシタ, リョウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyashita, Ryohei","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"右手, 浩一","creatorNameLang":"ja"},{"creatorName":"ウテ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Ute, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"右手","familyNameLang":"ja"},{"familyName":"ウテ","familyNameLang":"ja-Kana"},{"familyName":"Ute","familyNameLang":"en"}],"givenNames":[{"givenName":"浩一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"239","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"151610/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/151610/profile-ja.html"},{"nameIdentifier":"30176713","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30176713"}]},{"creatorNames":[{"creatorName":"オオハマ, タケシ","creatorNameLang":"ja"},{"creatorName":"オオハマ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohama, Takeshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-02-08"}],"displaytype":"detail","filename":"memb_12_8_782.pdf","filesize":[{"value":"2.41 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010642/files/memb_12_8_782.pdf"},"version_id":"77e0babf-3164-4e60-9ae5-4d74621235f0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"antibacterial agent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cyanoacrylate nanoparticle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"membrane damage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive oxygen species","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stress response","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of the Growth-Inhibitory Spectrum of Three Types of Cyanoacrylate Nanoparticles on Gram-Positive and Gram-Negative Bacteria","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of the Growth-Inhibitory Spectrum of Three Types of Cyanoacrylate Nanoparticles on Gram-Positive and Gram-Negative Bacteria","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-08"},"publish_date":"2023-02-08","publish_status":"0","recid":"2010642","relation_version_is_last":true,"title":["Evaluation of the Growth-Inhibitory Spectrum of Three Types of Cyanoacrylate Nanoparticles on Gram-Positive and Gram-Negative Bacteria"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T05:38:34.268147+00:00"}