{"created":"2024-12-12T09:11:47.065992+00:00","id":2010714,"links":{},"metadata":{"_buckets":{"deposit":"3ee892da-c598-45b9-88f5-1396be66fa93"},"_deposit":{"created_by":7,"id":"2010714","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010714"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010714","sets":["1713853213384:1713853295607"]},"author_link":["1215"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-01-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"100728","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Reproductive Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deletion of the azoospermia factor c (AZFc), located on the long arm of the Y chromosome, is a cause of male infertility. The structure of the Y chromosome is diversified by the copy number of various genes, such as deleted in azoospermia (DAZ), basic protein Y2, chromodomain Y1, testis-specific transcript Y-linked 4, and Golgi autoantigen golgin subfamily a2 like Y, located in the AZF region. In this study, we investigated the deletion of each gene copy and analyzed its relationship with Japanese male infertility. Deletions of single nucleotide variants of each gene copy in 721 proven fertile men as controls, 139 patients with non-obstructive azoospermia (NOA), and 56 patients with oligozoospermia (OS) were analyzed via polymerase chain reaction-restriction fragment length polymorphism analysis. Their association with infertility was analyzed using logistic regression analysis adjusted for the Y-chromosome haplogroup, D1a2a. Deletions of DAZ/II in the r1 region and DAZ/V in the r1 and r2 regions showed significant associations with NOA (odds ratio [OR] = 4.15, 95% confidence interval [CI] = 1.18–14.6, P = 0.026; OR = 4.19, 95% CI = 1.19–14.7, P = 0.025, respectively). They did not show any association with OS. Partial deletion of the AZFc region affects spermatogenesis in Japanese male.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Biology of Reproduction","subitem_publisher_language":"en"},{"subitem_publisher":"Institute of Animal Reproduction and Food Research of Polish Academy of Sciences","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"1642431X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"2300732X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12796059","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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コウスケ","creatorNameLang":"ja"},{"creatorName":"コジョウ, コウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kojo, Kosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツチヤ, ハルキ","creatorNameLang":"ja"},{"creatorName":"ツチヤ, ハルキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchiya, Haruki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クロベ, マサヒロ","creatorNameLang":"ja"},{"creatorName":"クロベ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kurobe, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウチダ, マサヒロ","creatorNameLang":"ja"},{"creatorName":"ウチダ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Uchida, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマサキ, カズミツ","creatorNameLang":"ja"},{"creatorName":"ヤマサキ, カズミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamasaki, Kazumitsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワモト, テルアキ","creatorNameLang":"ja"},{"creatorName":"イワモト, テルアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwamoto, Teruaki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐藤, 陽一","creatorNameLang":"ja"},{"creatorName":"サトウ, ヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Youichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"},{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"陽一","givenNameLang":"ja"},{"givenName":"ヨウイチ","givenNameLang":"ja-Kana"},{"givenName":"Youichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1215","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"73845/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/73845/profile-ja.html"},{"nameIdentifier":"10363160","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10363160"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-01-12"}],"displaytype":"detail","filename":"repbio_23_1_100728.pdf","filesize":[{"value":"524 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010714/files/repbio_23_1_100728.pdf"},"version_id":"df88cd6a-5ec6-445d-af15-ab392981ee46"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Y chromosome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"AZF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-obstructive azoospermia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Infertility","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Japanese men","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Analysis of the correlation between gene copy deletion in the AZFc region and male infertility in Japanese men","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of the correlation between gene copy deletion in the AZFc region and male infertility in Japanese men","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-20"},"publish_date":"2023-01-20","publish_status":"0","recid":"2010714","relation_version_is_last":true,"title":["Analysis of the correlation between gene copy deletion in the AZFc region and male infertility in Japanese men"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-31T06:20:36.732780+00:00"}