{"created":"2024-12-12T09:17:20.706461+00:00","id":2010777,"links":{},"metadata":{"_buckets":{"deposit":"4f7ddd27-118a-486c-9081-c7280533e9ed"},"_deposit":{"created_by":7,"id":"2010777","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010777"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010777","sets":["1713853213384:1713853295607"]},"author_link":["709","287","882","175","633","677","349","852","1572"],"control_number":"2010777","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-08-14","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"2657","bibliographicPageStart":"2646","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Cancer Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: We analyzed the association between the modified albumin–bilirubin (mALBI) grade and therapeutic efficacy of atezolizumab plus bevacizumab (Atezo+Bev) for the treatment of unresectable hepatocellular carcinoma (u-HCC).\nMethods: In this retrospective observational study, we included 71 u-HCC patients treated with Atezo+Bev between September 2020 and September 2021. Patients were grouped corresponding to the mALBI grade at the start of treatment (mALBI 1+2a or mALBI 2b+3) and analyzed for therapeutic effect and the transition rate to secondary treatment.\nResults: According to the Response Evaluation Criteria in Solid Tumors, the overall response rate was significantly higher for the mALBI 1+2a group, than for the mALBI 2b+3 group, with 26.2% and 3.4%, respectively. The progression-free survival (PFS) was significantly longer in the mALBI 1+2a group (10.5 months) than in the mALBI 2b+3 group (3.0 months). In the multivariate analysis, an mALBI of 1+2a was found to be an independent factor of PFS. The rate of second-line treatment with multi-targeted agents was also significantly higher in the mALBI 1+2a group.\nConclusions: In real-world practice, Atezo+Bev treatment might have higher therapeutic efficacy in u-HCC patients with mALBI 1+2a.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20457634","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/cam4.5145"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/cam4.5145","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"389441"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"友成, 哲","creatorNameLang":"ja"},{"creatorName":"トモナリ, テツ","creatorNameLang":"ja-Kana"},{"creatorName":"Tomonari, Tetsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"友成","familyNameLang":"ja"},{"familyName":"トモナリ","familyNameLang":"ja-Kana"},{"familyName":"Tomonari","familyNameLang":"en"}],"givenNames":[{"givenName":"哲","givenNameLang":"ja"},{"givenName":"テツ","givenNameLang":"ja-Kana"},{"givenName":"Tetsu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"277740/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/277740/profile-ja.html"},{"nameIdentifier":"20556807","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20556807"}]},{"creatorNames":[{"creatorName":"タニ, ジョウジ","creatorNameLang":"ja"},{"creatorName":"タニ, ジョウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Tani, Joji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐藤, 康史","creatorNameLang":"ja"},{"creatorName":"サトウ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Yasushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"},{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"康史","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"},{"givenName":"Yasushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"852","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"321662/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/321662/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"田中, 宏典","creatorNameLang":"ja"},{"creatorName":"タナカ, ヒロノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Hironori","creatorNameLang":"en"}],"familyNames":[{"familyName":"田中","familyNameLang":"ja"},{"familyName":"タナカ","familyNameLang":"ja-Kana"},{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"宏典","givenNameLang":"ja"},{"givenName":"ヒロノリ","givenNameLang":"ja-Kana"},{"givenName":"Hironori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"882","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"325239/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/325239/profile-ja.html"}]},{"creatorNames":[{"creatorName":"田中, 貴大","creatorNameLang":"ja"},{"creatorName":"タナカ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Takahiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"谷口, 達哉","creatorNameLang":"ja"},{"creatorName":"タニグチ, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Taniguchi, Tatsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"谷口","familyNameLang":"ja"},{"familyName":"タニグチ","familyNameLang":"ja-Kana"},{"familyName":"Taniguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"達哉","givenNameLang":"ja"},{"givenName":"タツヤ","givenNameLang":"ja-Kana"},{"givenName":"Tatsuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70518232","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70518232"}]},{"creatorNames":[{"creatorName":"モリシタ, アサヒロ","creatorNameLang":"ja"},{"creatorName":"モリシタ, アサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Morishita, Asahiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岡本, 耕一","creatorNameLang":"ja"},{"creatorName":"オカモト, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Okamoto, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"岡本","familyNameLang":"ja"},{"familyName":"オカモト","familyNameLang":"ja-Kana"},{"familyName":"Okamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"耕一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"349","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"179139/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/179139/profile-ja.html"},{"nameIdentifier":"60531374","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60531374"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"曽我部, 正弘","creatorNameLang":"ja"},{"creatorName":"ソガベ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sogabe, Masahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"曽我部","familyNameLang":"ja"},{"familyName":"ソガベ","familyNameLang":"ja-Kana"},{"familyName":"Sogabe","familyNameLang":"en"}],"givenNames":[{"givenName":"正弘","givenNameLang":"ja"},{"givenName":"マサヒロ","givenNameLang":"ja-Kana"},{"givenName":"Masahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"274188/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/274188/profile-ja.html"},{"nameIdentifier":"60732790","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60732790"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宮本, 弘志","creatorNameLang":"ja"},{"creatorName":"ミヤモト, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyamoto, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮本","familyNameLang":"ja"},{"familyName":"ミヤモト","familyNameLang":"ja-Kana"},{"familyName":"Miyamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"弘志","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"175","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"111468/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/111468/profile-ja.html"},{"nameIdentifier":"90398024","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90398024"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"六車, 直樹","creatorNameLang":"ja"},{"creatorName":"ムグルマ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Muguruma, Naoki","creatorNameLang":"en"}],"familyNames":[{"familyName":"六車","familyNameLang":"ja"},{"familyName":"ムグルマ","familyNameLang":"ja-Kana"},{"familyName":"Muguruma","familyNameLang":"en"}],"givenNames":[{"givenName":"直樹","givenNameLang":"ja"},{"givenName":"ナオキ","givenNameLang":"ja-Kana"},{"givenName":"Naoki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1572","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60123/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60123/profile-ja.html"},{"nameIdentifier":"90325283","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90325283"}]},{"creatorNames":[{"creatorName":"マサキ, ツトム","creatorNameLang":"ja"},{"creatorName":"マサキ, ツトム","creatorNameLang":"ja-Kana"},{"creatorName":"Masaki, Tsutomu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"高山, 哲治","creatorNameLang":"ja"},{"creatorName":"タカヤマ, テツジ","creatorNameLang":"ja-Kana"},{"creatorName":"Takayama, Tetsuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"高山","familyNameLang":"ja"},{"familyName":"タカヤマ","familyNameLang":"ja-Kana"},{"familyName":"Takayama","familyNameLang":"en"}],"givenNames":[{"givenName":"哲治","givenNameLang":"ja"},{"givenName":"テツジ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"287","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"169695/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/169695/profile-ja.html"},{"nameIdentifier":"10284994","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10284994"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-03"}],"displaytype":"detail","filename":"cam_12_3_2646.pdf","filesize":[{"value":"642 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010777/files/cam_12_3_2646.pdf"},"version_id":"7c49701a-82e1-4d5a-b37f-5dedfea58523"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"atezolizumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bevacizumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Initial therapeutic results of atezolizumab plus bevacizumab for unresectable advanced hepatocellular carcinoma and the importance of hepatic functional reserve","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Initial therapeutic results of atezolizumab plus bevacizumab for unresectable advanced hepatocellular carcinoma and the importance of hepatic functional reserve","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-03"},"publish_date":"2023-03-03","publish_status":"0","recid":"2010777","relation_version_is_last":true,"title":["Initial therapeutic results of atezolizumab plus bevacizumab for unresectable advanced hepatocellular carcinoma and the importance of hepatic functional reserve"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:58:41.304402+00:00"}