{"created":"2024-12-12T09:17:27.010134+00:00","id":2010778,"links":{},"metadata":{"_buckets":{"deposit":"be4b70ff-be75-4acf-bdd4-b1562260c1c1"},"_deposit":{"created_by":7,"id":"2010778","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010778"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010778","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["852","349","936","175","1572","287"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ResveratrolはLEF1を抑制することで大腸腺腫の発生を抑制する；connectivity mapを用いた網羅的解析","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"4384","bibliographicPageStart":"4374","bibliographicVolumeNumber":"113","bibliographic_titles":[{"bibliographic_title":"Cancer Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although many chemopreventive studies on colorectal tumors have been reported, no effective and safe preventive agent is currently available. We searched for candidate preventive compounds against colorectal tumor comprehensively from United States Food and Drug Administration (FDA)-approved compounds by using connectivity map (CMAP) analysis coupled with in vitro screening with colorectal adenoma (CRA) patient-derived organoids (PDOs). We generated CRA-specific gene signatures based on the DNA microarray analysis of CRA and normal epithelial specimens, applied them to CMAP analysis with 1309 FDA-approved compounds, and identified 121 candidate compounds that should cancel the gene signatures. We narrowed them down to 15 compounds, and evaluated their inhibitory effects on the growth of CRA-PDOs in vitro. We finally identified resveratrol, one of the polyphenolic phytochemicals, as a compound showing the strongest inhibitory effect on the growth of CRA-PDOs compared with normal epithelial PDOs. When resveratrol was administered to ApcMin/+ mice at 15 or 30 mg/kg, the number of polyps (adenomas) was significantly reduced in both groups compared with control mice. Similarly, the number of polyps (adenomas) was significantly reduced in azoxymethane-injected rats treated with 10 or 100 mg/resveratrol compared with control rats. Microarray analysis of adenomas from resveratrol-treated rats revealed the highest change (downregulation) in expression of LEF1, a key molecule in the Wnt signaling pathway. Treatment with resveratrol significantly downregulated the Wnt-target gene (MYC) in CRA-PDOs. Our data demonstrated that resveratrol can be the most effective compound for chemoprevention of colorectal tumors, the efficacy of which is mediated through suppression of LEF1 expression in the Wnt signaling pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Cancer Association","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13497006","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3670号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-01-26"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Hironori Wadaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1552号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1111/cas.15576"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/cas.15576","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"392599"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和田, 浩典","creatorNameLang":"ja"},{"creatorName":"ワダ, ヒロノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Wada, Hironori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 康史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"フジモト, ショウタ","creatorNameLang":"ja"},{"creatorName":"フジモト, ショウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Shota","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岡本, 耕一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"板東, 正浩","creatorNameLang":"ja"},{"creatorName":"バンドウ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"川口, 智之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本, 弘志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"六車, 直樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ホリモト, カツヒサ","creatorNameLang":"ja"},{"creatorName":"ホリモト, カツヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Horimoto, Katsuhisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツザワ, ユイ","creatorNameLang":"ja"},{"creatorName":"マツザワ, ユイ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuzawa, Yui","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムトウ, ミチヒロ","creatorNameLang":"ja"},{"creatorName":"ムトウ, ミチヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Mutoh, Michihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"高山, 哲治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"287","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-11"}],"displaytype":"detail","filename":"k3670_abstract.pdf","filesize":[{"value":"128 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2010778/files/k3670_abstract.pdf"},"version_id":"49990e3d-7201-4249-96d8-22412ed5fd4b"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-11"}],"displaytype":"detail","filename":"k3670_review.pdf","filesize":[{"value":"114 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2010778/files/k3670_review.pdf"},"version_id":"c8830f54-c7e1-49a8-ab80-13dd353b7dc2"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-11"}],"displaytype":"detail","filename":"k3670_fulltext.pdf","filesize":[{"value":"21.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010778/files/k3670_fulltext.pdf"},"version_id":"f7f50f54-1d01-4e95-aba0-977306977ed9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"chemoprevention","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal adenoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"connectivity map","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LEF1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"resveratrol","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Resveratrol inhibits development of colorectal adenoma via suppression of LEF1; comprehensive analysis with connectivity map","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Resveratrol inhibits development of colorectal adenoma via suppression of LEF1; comprehensive analysis with connectivity map","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-03"},"publish_date":"2023-03-03","publish_status":"0","recid":"2010778","relation_version_is_last":true,"title":["Resveratrol inhibits development of colorectal adenoma via suppression of LEF1; comprehensive analysis with connectivity map"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:17:39.298482+00:00"}