{"created":"2024-12-12T09:37:14.304649+00:00","id":2010979,"links":{},"metadata":{"_buckets":{"deposit":"a50bfbc6-3720-44a8-94f0-5e677f2facd1"},"_deposit":{"created_by":7,"id":"2010979","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2010979"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02010979","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1430","516","1579","1574","1584"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"新規総リン酸トランスポーター阻害剤EOS789のリン代謝に対する効果 : 既存リン吸着剤との比較","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"The physiological effects of EOS789","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"270","bibliographicPageStart":"260","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Inorganic phosphate (Pi) binders are the only pharmacologic treatment approved for hyperphosphatemia. However, Pi binders induce the expression of intestinal Pi transporters and have limited effects on the inhibition of Pi transport. EOS789, a novel pan-Pi transporter inhibitor, reportedly has potent efficacy in treating hyperphosphatemia. We investigated the properties of EOS789 with comparison to a conventional Pi binder. Methods: Protein and mRNA expression levels of Pi transporters were measured in intestinal and kidney tissues from male Wistar rats fed diets supplemented with EOS789 or lanthanum carbonate (LC). 32Pi permeability was measured in intestinal tissues from normal rats using a chamber. Results: Increased protein levels of NaPi-2b, an intestinal Pi transporter, and luminal Pi removal were observed in rats treated with LC but not in rats treated with EOS789. EOS789 but not LC suppressed intestinal protein levels of the Pi transporter Pit-1 and sodium / hydrogen exchanger isoform 3. 32Pi flux experiments using small intestine tissues from rats demonstrated that EOS789 may affect transcellular Pi transport in addition to paracellular Pi transport. Conclusion: EOS789 has differing regulatory effects on Pi metabolism compared to LC. The properties of EOS789 may compensate for the limitations of LC therapy. The combined or selective use of EOS789 and conventional Pi binders may allow tighter control of hyperphosphatemia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokushima University Faculty of Medicine","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3733号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-24"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Kazuya Tanifujiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科栄養学研究科（医科栄養学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第298号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.70.260"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.70.260","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"397418"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"谷藤, 和也","creatorNameLang":"ja"},{"creatorName":"タニフジ, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanifuji, Kazuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"塩﨑, 雄治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"コイケ, メグミ","creatorNameLang":"ja"},{"creatorName":"コイケ, メグミ","creatorNameLang":"ja-Kana"},{"creatorName":"Koike, Megumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウガ, ミノリ","creatorNameLang":"ja"},{"creatorName":"ウガ, ミノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Uga, Minori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コミヤ, アオイ","creatorNameLang":"ja"},{"creatorName":"コミヤ, アオイ","creatorNameLang":"ja-Kana"},{"creatorName":"Komiya, Aoi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミウラ, ミヅキ","creatorNameLang":"ja"},{"creatorName":"ミウラ, ミヅキ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Mizuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒガシ, アヤミ","creatorNameLang":"ja"},{"creatorName":"ヒガシ, アヤミ","creatorNameLang":"ja-Kana"},{"creatorName":"Higashi, Ayami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"下畑, 隆明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙橋, 章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イシヅカ, ノリコ","creatorNameLang":"ja"},{"creatorName":"イシヅカ, ノリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishizuka, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハヤシ, ヒサヨシ","creatorNameLang":"ja"},{"creatorName":"ハヤシ, ヒサヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Hisayoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イチダ, ヤスヒロ","creatorNameLang":"ja"},{"creatorName":"イチダ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichida, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオトモ, シュウイチ","creatorNameLang":"ja"},{"creatorName":"オオトモ, シュウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohtomo, Shuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ホリバ, ナオシ","creatorNameLang":"ja"},{"creatorName":"ホリバ, ナオシ","creatorNameLang":"ja-Kana"},{"creatorName":"Horiba, Naoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宮本, 賢一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"瀬川, 博子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1584","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-05-15"}],"displaytype":"detail","filename":"k3733_abstract_review.pdf","filesize":[{"value":"211 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2010979/files/k3733_abstract_review.pdf"},"version_id":"5f8ec151-a3b8-4d7f-b33c-6913a526e1db"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-05-15"}],"displaytype":"detail","filename":"k3733_fulltext.pdf","filesize":[{"value":"1.42 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2010979/files/k3733_fulltext.pdf"},"version_id":"c7a4f6bc-f1fd-48d2-95ea-171497bf7521"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hyperphosphatemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CKD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intestine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphate transporter","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of EOS789, a novel pan-phosphate transporter inhibitor, on phosphate metabolism : Comparison with a conventional phosphate binder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of EOS789, a novel pan-phosphate transporter inhibitor, on phosphate metabolism : Comparison with a conventional phosphate binder","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-05-15"},"publish_date":"2023-05-15","publish_status":"0","recid":"2010979","relation_version_is_last":true,"title":["Effects of EOS789, a novel pan-phosphate transporter inhibitor, on phosphate metabolism : Comparison with a conventional phosphate binder"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:37:26.758896+00:00"}