{"created":"2024-12-12T09:39:33.728689+00:00","id":2011001,"links":{},"metadata":{"_buckets":{"deposit":"de34d050-6352-443b-828e-a96a05f79147"},"_deposit":{"created_by":7,"id":"2011001","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011001"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011001","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1568","711","519","992","960","1471","332","267","948","344","334","1254","1643","1557","1546"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"日本人の限局性前立腺癌患者における小線源療法後の前立腺特異抗原レベルは晩期生化学的再発に影響する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Long-term Outcomes of Brachytherapy in Japanese Patients","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"746","bibliographicPageStart":"738","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"in vivo","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim: Evaluation of long-term outcomes is essential for the successful treatment of localized prostate cancer; however, the risk of late recurrence following brachytherapy is still not clear. This study aimed to evaluate the long-term outcomes of low-dose-rate brachytherapy (LDR-BT) for localized prostate cancer in Japanese patients and identify factors associated with late recurrence after treatment. Patients and Methods: This single-center, cohort study included patients who underwent LDR-BT at the Tokushima University Hospital in Japan between July 2004 and January 2015; 418 patients, who were followed-up at least 7 years after LDR-BT, were included in the study. Biochemical progression free survival (bPFS) was defined according to the Phoenix definition (nadir PSA+2 ng/ml) and bPFS and cancer specific survival (CSS) were calculated using Kaplan-Meier survival curves. Univariate and multivariate analyses were performed using Cox proportional hazard regression models. Results: Approximately half of the patients with PSA >0.5 ng/ml at 5 years after LDR-BT had a recurrence within the next 2 years. However, only 1.4% of the patients with a PSA ≤0.2 ng/ml at 5 years post-treatment showed tumor recurrence, including those at high risk of treatment failure according to the D’Amico classification. In multivariate analysis, PSA level at 5 years post-treatment was the only predictor of late recurrence after 7 years of treatment. Conclusion: PSA levels at 5 years post-treatment were associated with long-term recurrence of localized prostate cancer, which can help alleviate patient anxiety concerning prostate cancer recurrence if PSA levels remain low at 5 years after LDR-BT.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Institute of Anticancer Research","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"0258851X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17917549","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10714348","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3680号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者YOSHITERU UENOの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1568号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.21873/invivo.13136"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/invivo.13136","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上野, 恵輝","creatorNameLang":"ja"},{"creatorName":"ウエノ, ヨシテル","creatorNameLang":"ja-Kana"},{"creatorName":"Ueno, Yoshiteru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"福森, 知治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"楠原, 義人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"布川, 朋也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"519","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"津田, 恵","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大豆本, 圭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木, 雄太郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"トミダ, リョウタロウ","creatorNameLang":"ja"},{"creatorName":"トミダ, リョウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tomida, Ryotaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 恭代","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"332","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口, 邦久","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"外礒, 千智","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保, 亜貴子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川中, 崇","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古谷, 俊介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生島, 仁史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 正幸","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金山, 博臣","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1546","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-05-25"}],"displaytype":"detail","filename":"k3680_abstract.pdf","filesize":[{"value":"123 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011001/files/k3680_abstract.pdf"},"version_id":"4fa807dc-8b26-426b-834c-2d0cc04646d0"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-05-25"}],"displaytype":"detail","filename":"k3680_review.pdf","filesize":[{"value":"101 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2011001/files/k3680_review.pdf"},"version_id":"f5ba0e2d-1950-47b4-95a8-4b5bb241f932"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-05-25"}],"displaytype":"detail","filename":"k3680_fulltext.pdf","filesize":[{"value":"807 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outcomes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Prostate-specific Antigen Levels Following Brachytherapy Impact Late Biochemical Recurrence in Japanese Patients With Localized Prostate Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prostate-specific Antigen Levels Following Brachytherapy Impact Late Biochemical Recurrence in Japanese Patients With Localized Prostate Cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-05-25"},"publish_date":"2023-05-25","publish_status":"0","recid":"2011001","relation_version_is_last":true,"title":["Prostate-specific Antigen Levels Following Brachytherapy Impact Late Biochemical Recurrence in Japanese Patients With Localized Prostate Cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:39:46.076589+00:00"}