{"created":"2024-12-12T09:43:03.599392+00:00","id":2011030,"links":{},"metadata":{"_buckets":{"deposit":"69afcd60-15a7-49dd-bad5-007224c9d64f"},"_deposit":{"created_by":7,"id":"2011030","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011030"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011030","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["792","193","265","702","517","885","1253"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"L型アミノ酸輸送体3が肝細胞癌の予後に与える影響","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"IMPACT OF LAT3 ON HCC","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"418","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Oncology Letters","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of the present study was to investigate the impact of L‑type amino acid transporter 3 (LAT3) expression on the prognosis of hepatocellular carcinoma (HCC). A total of 135 patients who had undergone initial hepatic resection for HCC at Tokushima University Hospital (Tokushima, Japan) were enrolled in the present study. Immunohistochemical analysis of LAT3 and phosphorylated AKT (p‑AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were compared between the LAT3‑high and ‑low expression groups. The results demonstrated that the LAT3‑high group showed significantly higher protein induced by vitamin K absence‑II levels (P=0.01) compared with the LAT3‑low group. The LAT3‑high group showed significantly worse prognosis compared with the LAT3‑low group regarding cancer‑specific survival and disease‑free survival (P<0.05). Multivariate analysis revealed that high LAT3 expression and multiple tumors were independent prognostic factors for cancer‑specific survival. Furthermore, the rate of p‑AKT‑positive cases was higher in the LAT3‑high group than in the LAT3‑low group. Overall, these findings suggested that LAT3 expression was associated with poor prognosis of HCC and high p‑AKT expression.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.( https://creativecommons.org/licenses/by-nc-nd/4.0/ )","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17921074","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17921082","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3691号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Baasansuren Selengeの学位論文として提出され，学位審査・授与の対象となっている。\n著者名英表記誤記あり　(誤)BAASANSVREN SELENGE→(正)BAASANSUREN SELENGE\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1556号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3892/ol.2022.13538"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/ol.2022.13538","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"396262"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"バーサンスレン, セレンゲ","creatorNameLang":"ja"},{"creatorName":"バーサンスレン, セレンゲ","creatorNameLang":"ja-Kana"},{"creatorName":"Baasansuren, Selenge","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山田, 眞一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森根, 裕二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池本, 哲也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤, 裕","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙須, 千絵","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺奥, 大貴","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 光生","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1253","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-14"}],"displaytype":"detail","filename":"k3691_abstract.pdf","filesize":[{"value":"96.5 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011030/files/k3691_abstract.pdf"},"version_id":"ccd2d0f0-fcfc-45da-ba24-d936c1f372c8"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-14"}],"displaytype":"detail","filename":"k3691_review.pdf","filesize":[{"value":"92.9 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2011030/files/k3691_review.pdf"},"version_id":"9fe20327-c164-41e1-ac5a-810fbf72d130"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-14"}],"displaytype":"detail","filename":"k3691_fulltext.pdf","filesize":[{"value":"1.09 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011030/files/k3691_fulltext.pdf"},"version_id":"e69f7cb6-fb0a-4bd6-86ab-50fc5ff31c4d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LAT3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HCC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amino acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"leucine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p‑AKT","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Impact of L-type amino acid transporter 3 on the prognosis of hepatocellular carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of L-type amino acid transporter 3 on the prognosis of hepatocellular carcinoma","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-14"},"publish_date":"2023-06-14","publish_status":"0","recid":"2011030","relation_version_is_last":true,"title":["Impact of L-type amino acid transporter 3 on the prognosis of hepatocellular carcinoma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:43:14.315043+00:00"}