{"created":"2024-12-12T09:43:32.595294+00:00","id":2011035,"links":{},"metadata":{"_buckets":{"deposit":"535f4a32-9b42-4dcc-8689-ee1e1d074a2b"},"_deposit":{"created_by":7,"id":"2011035","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011035"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011035","sets":["1713853213384:1713853295607"]},"author_link":["1188"],"control_number":"2011035","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"2485","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Despite recent developments in protein structure prediction, the process of the structure formation, folding, remains poorly understood. Notably, folding of multidomain proteins, which involves multiple steps of segmental folding, is one of the biggest questions in protein science. Multidomain protein folding often requires the assistance of molecular chaperones. Molecular chaperones promote or delay the folding of the client protein, but the detailed mechanisms are still unclear. This review summarizes the findings of biophysical and structural studies on the mechanism of multidomain protein folding mediated by molecular chaperones and explains how molecular chaperones recognize the client proteins and alter their folding properties. Furthermore, we introduce several recent studies that describe the concept of kinetics–activity relationships to explain the mechanism of functional diversity of molecular chaperones.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/ijms23052485"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms23052485","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"397613"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"カワゴエ, ソウイチロウ","creatorNameLang":"ja"},{"creatorName":"カワゴエ, ソウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawagoe, Soichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシモリ, コウイチロウ","creatorNameLang":"ja"},{"creatorName":"イシモリ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishimori, Koichiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"齋尾, 智英","creatorNameLang":"ja"},{"creatorName":"サイオ, トモヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Saio, Tomohide","creatorNameLang":"en"}],"familyNames":[{"familyName":"齋尾","familyNameLang":"ja"},{"familyName":"サイオ","familyNameLang":"ja-Kana"},{"familyName":"Saio","familyNameLang":"en"}],"givenNames":[{"givenName":"智英","givenNameLang":"ja"},{"givenName":"トモヒデ","givenNameLang":"ja-Kana"},{"givenName":"Tomohide","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1188","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"371222/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/371222/profile-ja.html"},{"nameIdentifier":"80740802","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80740802"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-07"}],"displaytype":"detail","filename":"ijms_23_5_2485.pdf","filesize":[{"value":"26.4 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011035/files/ijms_23_5_2485.pdf"},"version_id":"d34eb8c9-c6ad-4fd7-a0e4-4cf9fb63da61"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"molecular chaperone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biophysical method","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multidomain protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"binding kinetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein structure","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-07"},"publish_date":"2023-06-07","publish_status":"0","recid":"2011035","relation_version_is_last":true,"title":["Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-31T05:14:31.262073+00:00"}