{"created":"2024-12-12T09:44:05.160709+00:00","id":2011040,"links":{},"metadata":{"_buckets":{"deposit":"7a17b929-c206-44aa-be91-5e1e3a243d9a"},"_deposit":{"created_by":7,"id":"2011040","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011040"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011040","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["248","479","1549"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"FGF21欠損マウスにおいて社会的ストレスが睡眠へ及ぼす影響","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-13","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"47","bibliographicPageStart":"40","bibliographicVolumeNumber":"191","bibliographic_titles":[{"bibliographic_title":"Brain Research Bulletin","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although several previous studies have suggested a relationship between sleep and the stress response, the mechanism underlying this relationship remains largely unknown. Here, we show that fibroblast growth factor 21 (FGF21), a lipid metabolism-related hormone, may play a role in this relationship. In this study, we examined differences in the stress response between FGF21 knockout (KO) mice and wild-type (WT) mice after social defeat stress (SDS). When the amount of non-rapid eye movement (NREM) sleep, rapid eye movement (REM) sleep and wakefulness were averaged over the dark period after SDS, only KO mice showed significant differences in NREM sleep and wakefulness. In the social interaction test, KO mice seemed to be more prone to social avoidance. Our real-time (RT) -PCR results revealed that the mRNA expression of the stress- and sleep-related gene gamma-aminobutyric acid A receptor subunit alpha 2 was significantly lower in WT mice than in KO mice. Moreover, KO mice showed lower plasma levels of ketone bodies, which also affect sleep/wake regulation, than WT mice. These results suggested that FGF21 might influence sleep/wake regulation by inducing production of an anti-stress agent and/or ketone bodies, which may result in resilience to social stress.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"18732747","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11522003","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3693号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Saori Hokariの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1559号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.brainresbull.2022.10.005"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.brainresbull.2022.10.005","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"穂苅, 早織","creatorNameLang":"ja"},{"creatorName":"ホカリ, サオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Hokari, Saori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"近久, 幸子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志内, 哲也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ナカヤマ, ヨシアキ","creatorNameLang":"ja"},{"creatorName":"ナカヤマ, ヨシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakayama, Yoshiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コニシ, モリチカ","creatorNameLang":"ja"},{"creatorName":"コニシ, モリチカ","creatorNameLang":"ja-Kana"},{"creatorName":"Konishi, Morichika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニシノ, セイジ","creatorNameLang":"ja"},{"creatorName":"ニシノ, セイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishino, Seiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, ノブユキ","creatorNameLang":"ja"},{"creatorName":"イトウ, ノブユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Itoh, Nobuyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"勢井, 宏義","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1549","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-14"}],"displaytype":"detail","filename":"k3693_abstract.pdf","filesize":[{"value":"122 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011040/files/k3693_abstract.pdf"},"version_id":"0677c5f7-c6f7-4cc4-877f-8f94be41828a"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-14"}],"displaytype":"detail","filename":"k3693_review.pdf","filesize":[{"value":"96.1 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2011040/files/k3693_review.pdf"},"version_id":"15551857-9a92-46e8-92b6-733e79a9fb90"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-14"}],"displaytype":"detail","filename":"k3693_fulltext.pdf","filesize":[{"value":"1.83 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011040/files/k3693_fulltext.pdf"},"version_id":"4d53d830-7271-46c0-a49a-eac0ea158501"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"社会的ストレス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス応答","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"睡眠","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"FGF21","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ケトン体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Social stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stress response","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sleep","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ketone bodies","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Social stress alters sleep in FGF21-deficient mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Social stress alters sleep in FGF21-deficient mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-14"},"publish_date":"2023-06-14","publish_status":"0","recid":"2011040","relation_version_is_last":true,"title":["Social stress alters sleep in FGF21-deficient mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:44:17.070370+00:00"}