{"created":"2024-12-12T09:44:56.169638+00:00","id":2011048,"links":{},"metadata":{"_buckets":{"deposit":"18cf71e1-ffaa-49a4-9b9c-984a17d8b824"},"_deposit":{"created_by":7,"id":"2011048","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011048"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011048","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1616","676","571","1192","954","1556","1521"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ファルネソイドX受容体に対する刺激はマクロファージのM2分極化を促進する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-01-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1065790","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Frontiers in Immunology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in macrophage polarization. In this paper we demonstrated that stimulation of macrophages derived from the bone marrow using an FXR agonist activated polarization toward M2 but not M1 macrophages. The treatment of mice with chitin skewed macrophage polarization towards M2 macrophages, while co-treatment with an FXR agonist further promoted the polarization toward M2 macrophages in vivo. This skewed polarization towards M2 macrophages by an FXR agonist was accompanied by increased expression of signaling molecules related to the retinoic acid receptor. Inhibition of the retinoic acid receptor suppressed FXR agonist-mediated M2 macrophage polarization, indicating that this polarization was, at least, partly dependent on the retinoic acid receptor pathway. These data demonstrate that FXR has a role in polarization toward M2 macrophages and suggest a possible therapeutic potential of FXR agonists in M2 macrophage-related conditions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"16643224","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3701号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Thiranut Jaroonwitchawanの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1571号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3389/fimmu.2023.1065790"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fimmu.2023.1065790","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"394042"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ジャローンウイッチャワン, サラント","creatorNameLang":"ja"},{"creatorName":"ジャローンウイッチャワン, サラント","creatorNameLang":"ja-Kana"},{"creatorName":"Jaroonwitchawan, Thiranut","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"有持, 秀喜","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木, 由紀","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石舟, 智恵子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"近藤, 博之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大塚, 邦紘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"九十九, 伸一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安友, 康二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1521","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3701_abstract.pdf","filesize":[{"value":"125 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011048/files/k3701_abstract.pdf"},"version_id":"443fb8b5-225e-4821-bbb1-ff487bb2cf1d"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3701_review.pdf","filesize":[{"value":"103 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differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tissue repair","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Stimulation of the farnesoid X receptor promotes M2 macrophage polarization","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Stimulation of the farnesoid X receptor promotes M2 macrophage polarization","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-20"},"publish_date":"2023-06-20","publish_status":"0","recid":"2011048","relation_version_is_last":true,"title":["Stimulation of the farnesoid X receptor promotes M2 macrophage polarization"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:45:07.443748+00:00"}