{"created":"2024-12-12T09:46:14.302424+00:00","id":2011060,"links":{},"metadata":{"_buckets":{"deposit":"55802f80-9a44-4821-810e-2cd2d7ff3e13"},"_deposit":{"created_by":7,"id":"2011060","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011060"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011060","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["1683","954","813","1721"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"原発性シェーグレン症候群モデルマウスにおいて唾液腺Natural killer細胞の恒常性の破綻がIFN-γを介して自己免疫病変を増強する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1036787","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Frontiers in Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1, ILC2, lymphoid tissue-inducer (LTi) cells, and ILC3 cell, play a key role in various immune responses. Primary Sjögren’s syndrome (pSS) is an autoimmune disease characterized by chronic inflammation of exocrine glands, such as the lacrimal and salivary glands (SGs). The role of NK cells among ILCs in the pathogenesis of pSS is still unclear. In this study, the characteristics and subsets of NK cells in the salivary gland (SG) tissue were analyzed using a murine model of pSS.\nMethods: Multiple phenotypes and cytotoxic signature of the SG NK cells in control and pSS model mice were evaluated by flow cytometric analysis. Intracellular expression of interferon-γ (IFN-γ) among T cells and NK cells from the SG tissues was compared by in vitro experiments. In addition, pathological analysis was performed using anti-asialo-GM1 (ASGM1) antibody (Ab)-injected pSS model mice.\nResults: The number of conventional NK (cNK) cells in the SG of pSS model mice significantly increased compared with that in control mice at 6 weeks of age. The production level of IFN-γ was significantly higher in SG NK cells than in SG T cells. The depletion of NK cells by ASGM1 Ab altered the ratio of tissue resident NK (rNK) cells to cNK cells, which inhibited the injury to SG cells with the recovery of saliva secretion in pSS model mice.\nConclusion: The results indicate that SG cNK cells may enhance the autoreactive response in the target organ by upregulating of IFN-γ, whereas SG rNK cells protect target cells against T cell cytotoxicity. Therefore, the activation process and multiple functions of NK cells in the target organ could be helpful to develop potential markers for determining autoimmune disease activity and target molecules for incurable immune disorders.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"2296858X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3710号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Mami Satoの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学研究科（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第489号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3389/fmed.2022.1036787"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fmed.2022.1036787","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"395468"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 真美","creatorNameLang":"ja"},{"creatorName":"サトウ, マミ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Mami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"新垣, 理恵子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"タワラ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"タワラ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tawara, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナガオ, ルカ","creatorNameLang":"ja"},{"creatorName":"ナガオ, ルカ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagao, Ruka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タナカ, ヒデタカ","creatorNameLang":"ja"},{"creatorName":"タナカ, ヒデタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Hidetaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タムラ, カイ","creatorNameLang":"ja"},{"creatorName":"タムラ, カイ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamura, Kai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カワヒト, ユウキ","creatorNameLang":"ja"},{"creatorName":"カワヒト, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawahito, Yuhki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大塚, 邦紘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"牛尾, 綾","creatorNameLang":"ja"},{"creatorName":"ウシオ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Ushio, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"常松, 貴明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石丸, 直澄","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1721","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3710_abstract.pdf","filesize":[{"value":"207 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011060/files/k3710_abstract.pdf"},"version_id":"b3cd978b-a273-47c9-a3ec-ee1e6a4224af"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3710_review.pdf","filesize":[{"value":"42.4 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2011060/files/k3710_review.pdf"},"version_id":"e80f8451-d20c-4711-9292-7cc52f893320"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3710_fulltext.pdf","filesize":[{"value":"2.03 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011060/files/k3710_fulltext.pdf"},"version_id":"7bc4a4a6-d79e-48a9-bfbb-fc59e9b7353e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NK cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-γ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sjögren’s syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathology via IFN-γ in a mouse model of primary Sjögren’s syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathology via IFN-γ in a mouse model of primary Sjögren’s syndrome","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-20"},"publish_date":"2023-06-20","publish_status":"0","recid":"2011060","relation_version_is_last":true,"title":["Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathology via IFN-γ in a mouse model of primary Sjögren’s syndrome"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:46:24.572708+00:00"}