| Item type |
文献 / Documents(1) |
| 公開日 |
2023-06-15 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.2152/jmi.70.41 |
|
|
関連名称 |
10.2152/jmi.70.41 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Benefits of guideline-directed medical therapy to loop diuretics in management of heart failure |
| タイトル別表記 |
|
|
その他のタイトル |
Optimal medical therapy to diuretics |
| 著者 |
楠瀬, 賢也
オオクシ, ユウイチロウ
オカヤマ, ヨシヒロ
Zheng, Robert
ナカイ, ミチカズ
スミタ, ヨウコ
伊勢, 孝之
山口, 浩司
八木, 秀介
山田, 博胤
添木, 武
若槻, 哲三
佐田, 政隆
|
| 抄録 |
|
|
内容記述 |
Background : We sought to compare the outcomes of patients receiving combination therapy of diuretics and neurohormonal blockers, with a matched cohort with monotherapy of loop diuretics, using real-world big data. Methods : This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 78,685 patients who were first hospitalized with heart failure (HF) between April 2015 and March 2017. Propensity score (PS) was estimated with logistic regression model, with neurohormonal blockers (angiotensin-converting enzyme inhibitor : ACEi or angiotensin receptor blocker : ARB, β-blockers and mineralocorticoid receptor antagonists : MRA) as the dependent variable and 24 clinically relevant covariates to compare the in-hospital mortality between monotherapy of loop diuretics and combination therapies. Results : On PS-matched analysis, patients with ACEi / ARB, β-blockers, and MRA had lower total in-hospital mortality and in-hospital mortality within 7 days, 14 days and 30 days. In the sub-group analysis, regardless of clinical characteristics including elderly people and cancer, patients treated with a combination of loop diuretics and neurohormonal blockers had significantly lower in-hospital mortality than matched patients. Conclusions : Our data indicate the benefits of guideline-directed medical therapy to loop diuretics in the management of HF. |
| キーワード |
|
|
主題 |
heart failure |
| キーワード |
|
|
主題 |
angiotensin-converting enzyme inhibitor |
| キーワード |
|
|
主題 |
angiotensin receptor blocker |
| キーワード |
|
|
主題 |
β-blockers |
| キーワード |
|
|
主題 |
mineralocorticoid receptor antagonists |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 70,
号 1-2,
p. 41-53,
発行日 2023-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
| EID |
|
|
識別子 |
410616 |
| 言語 |
|
|
言語 |
eng |
jmi_70_1-2_41.pdf (1.13 MB)
