{"created":"2024-12-12T09:47:20.947380+00:00","id":2011071,"links":{},"metadata":{"_buckets":{"deposit":"79bffdb0-7bbe-469d-a288-8d37c08ca1b3"},"_deposit":{"created_by":7,"id":"2011071","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011071"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011071","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1507","949","761","1274","1585"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"液性因子および細胞性因子が成長期におけるリン誘導性の血管石灰化を抑制する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"204","bibliographicPageStart":"198","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth. Here, we have examined whether the defence system against Pi-induced vascular calcification can exist during the growth period using mice model. We found that calcification propensity of young serum (aged 3 weeks) was significantly lower than that of ‍adult serum (10 months), possibly due to high fetuin-A levels. In addition, when the aorta was cultured in high Pi medium in ‍vitro, obvious calcification was observed in the adult aorta but ‍not in the young aorta. Furthermore, culture in high Pi medium increased the mRNA level of tissue-nonspecific alkaline phosphatase (TNAP), which degrades pyrophosphate, only in the adult aorta. Collectively, our findings indicate that the aorta in growing mouse may be resistant to Pi-induced vascular calcification via a mechanism in which high serum fetuin-A levels and suppressed TNAP expression.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Free Radical Research Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3735号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-24"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Yuki Kameiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科栄養学研究科（医科栄養学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第300号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.23-11"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.23-11","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"亀井, 優輝","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"オクムラ, ヨウスケ","creatorNameLang":"ja"},{"creatorName":"オクムラ, ヨウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Okumura, Yosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アダチ, ユウイチロウ","creatorNameLang":"ja"},{"creatorName":"アダチ, ユウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Adachi, Yuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリ, ユウキ","creatorNameLang":"ja"},{"creatorName":"モリ, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サカイ, マイコ","creatorNameLang":"ja"},{"creatorName":"サカイ, マイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakai, Maiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大西, 康太","creatorNameLang":"ja"},{"creatorName":"オオニシ, コウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohnishi, Kohta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大南, 博和","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"増田, 真志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"(山中)奥村, 仙示","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹谷, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1585","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-06-20"}],"displaytype":"detail","filename":"k3735_abstract_review.pdf","filesize":[{"value":"204 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011071/files/k3735_abstract_review.pdf"},"version_id":"2c4bfa71-3ae5-475b-91fc-4de953e8f39b"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-01"}],"displaytype":"detail","filename":"k3735_fulltext.pdf","filesize":[{"value":"605 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011071/files/k3735_fulltext.pdf"},"version_id":"9612e490-ed31-448b-8747-9e9ae1d92293"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"chronic kidney disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hyperphosphatemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fetuin-A","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pyrophosphate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alkaline phosphatase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Humoral and Cellular Factors Inhibit Phosphate-Induced Vascular Calcification during the Growth Period","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Humoral and Cellular Factors Inhibit Phosphate-Induced Vascular Calcification during the Growth Period","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-20"},"publish_date":"2023-06-20","publish_status":"0","recid":"2011071","relation_version_is_last":true,"title":["Humoral and Cellular Factors Inhibit Phosphate-Induced Vascular Calcification during the Growth Period"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:47:34.289660+00:00"}