{"created":"2024-12-12T09:52:48.424230+00:00","id":2011126,"links":{},"metadata":{"_buckets":{"deposit":"4433dfcb-6bea-476a-bec6-353eb29c0ff3"},"_deposit":{"created_by":7,"id":"2011126","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011126"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011126","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["708","955","345","1624","1629","439"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"顕微授精後のヒト未受精卵に対するカルシウムイオノファとロスコビチンを併用した卵活性化の有用性","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Activation with a Ca ionophore and roscovitine is effective in terms of fertilization, especially in the TESE-ICSI treated cases.","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"324","bibliographicPageStart":"321","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective : The effects of oocyte activation with a Ca ionophore and roscovitine (Ca+R), a selective inhibitor of M-phase promoting factor, on unfertilized oocytes after intracytoplasmic sperm injection (ICSI) or testicular sperm extraction (TESE)-ICSI were evaluated. Method : Oocytes without pronuclei at 18 hours after ICSI were judged to be unfertilized and were exposed to the Ca ionophore A23187 (5 μM) with or without roscovitine (50 μM). The activation rate was measured 3, 7, and 18 hours later. Oocytes with two polar bodies and two pronuclei with a sperm tail were judged to have been activated. Results : At 18 hours, the activation rates in the control, Ca ionophore, and Ca+R groups were 3.5% (4 / 112), 26.9% (7 / 26), and 32.1% (17 / 53), respectively. The activation rate of the Ca+R group was significantly higher than that of the control and similar to that of the Ca ionophore group. Among the oocytes that remained unfertilized after TESE-ICSI, the activation rates of the Ca ionophore and Ca+R groups were 22.2% (2 / 9) and 43.8% (7 / 16), respectively. Conclusions : Sequential treatment with an Ca ionophore and roscovitine activates oocytes that remain unfertilized after ICSI. In TESE-ICSI, the activation rate tended to be increased by the co-administration of roscovitine with a Ca ionophore.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokushima University Faculty of Medicine","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3739号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-04-27"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Ayako Sutoの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1577号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.70.321"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.70.321","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"須藤, 文子","creatorNameLang":"ja"},{"creatorName":"ストウ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Suto, Ayako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤノ, ユウヤ","creatorNameLang":"ja"},{"creatorName":"ヤノ, ユウヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yano, Yuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 由理","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野口, 拓樹","creatorNameLang":"ja"},{"creatorName":"ノグチ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Noguchi, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケダ, アスカ","creatorNameLang":"ja"},{"creatorName":"タケダ, アスカ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeda, Asuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモト, ショウタ","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ショウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Shota","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"香川, 智洋","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 加奈子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヒノキオ, ケンジ","creatorNameLang":"ja"},{"creatorName":"ヒノキオ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Hinokio, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"桑原, 章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安井, 敏之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩佐, 武","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"439","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-04"}],"displaytype":"detail","filename":"k3739_abstract.pdf","filesize":[{"value":"166 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thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of activation with a Ca ionophore and roscovitine on the development of human oocytes that failed to fertilize after ICSI","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of activation with a Ca ionophore and roscovitine on the development of human oocytes that failed to fertilize after ICSI","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-07-04"},"publish_date":"2023-07-04","publish_status":"0","recid":"2011126","relation_version_is_last":true,"title":["Effects of activation with a Ca ionophore and roscovitine on the development of human oocytes that failed to fertilize after ICSI"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:53:02.451490+00:00"}