{"created":"2024-12-12T09:53:34.668741+00:00","id":2011134,"links":{},"metadata":{"_buckets":{"deposit":"8948b8df-e9e8-41a4-bc50-1e4eb00cbf40"},"_deposit":{"created_by":7,"id":"2011134","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011134"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011134","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["384","723","326","876","919","950","1488","1164","1514","230","323","1634"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"プロテアソーム阻害薬による骨髄腫骨病変部における優先的な骨形成のメカニズムについて","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-04-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"98","bibliographicPageStart":"88","bibliographicVolumeNumber":"118","bibliographic_titles":[{"bibliographic_title":"International Journal of Hematology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Proteasome inhibitors (PIs) can preferentially restore bone in bone-defective lesions of patients with multiple myeloma (MM) who respond favorably to these drugs. Most prior in vitro studies on PIs used continuous exposure to low PI concentrations, although pharmacokinetic analysis in patients has shown that serum concentrations of PIs change in a pulsatile manner. In the present study, we explored the effects of pulsatile treatment with PIs on bone metabolism to simulate in vivo PI pharmacokinetics. Pulsatile treatment with bortezomib, carfilzomib, or ixazomib induced MM cell death but only marginally affected the viability of osteoclasts (OCs) with F-actin ring formation. Pulsatile PI treatment suppressed osteoclastogenesis in OC precursors and bone resorption by mature OCs. OCs robustly enhanced osteoblastogenesis in cocultures with OCs and MC3T3-E1 pre-osteoblastic cells, indicating OC-mediated coupling to osteoblastogenesis. Importantly, pulsatile PI treatment did not impair robust OC-mediated osteoblastogenesis. These results suggest that PIs might sufficiently reduce MM cell-derived osteoblastogenesis inhibitors to permit OC-driven bone formation coupling while suppressing OC differentiation and activity in good responders to PIs. OC-mediated coupling to osteoblastogenesis appears to be a predominant mechanism for preferential occurrence of bone regeneration at sites of osteoclastic bone destruction in good responders.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09255710","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18653774","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10797094","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3741号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-06-08"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Emiko Nakaueの学位論文として提出され，学位審査・授与の対象となっている。\nThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12185-023-03601-2\n学位授与者所属 : 徳島大学大学院口腔科学研究科（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第497号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s12185-023-03601-2"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12185-023-03601-2","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"395242"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中上, 絵美子","creatorNameLang":"ja"},{"creatorName":"ナカウエ, エミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakaue, Emiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"寺町, 順平","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"天眞, 寛文","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"日浅, 雅博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田, 武志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"876","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"オダ, アスカ","creatorNameLang":"ja"},{"creatorName":"オダ, アスカ","creatorNameLang":"ja-Kana"},{"creatorName":"Oda, Asuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, ユウスケ","creatorNameLang":"ja"},{"creatorName":"イノウエ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"清水, 宗","creatorNameLang":"ja"},{"creatorName":"シミズ, ソウ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimizu, So","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒガ, ヨシキ","creatorNameLang":"ja"},{"creatorName":"ヒガ, ヨシキ","creatorNameLang":"ja-Kana"},{"creatorName":"Higa, Yoshiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"曽我部, 公子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大浦, 雅博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原, 倫世","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"住谷, 龍平","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"マルハシ, トモコ","creatorNameLang":"ja"},{"creatorName":"マルハシ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Maruhashi, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山上, 紘規","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤, 逸朗","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 栄二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安倍, 正博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1634","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-08-04"}],"displaytype":"detail","filename":"k3741_abstract.pdf","filesize":[{"value":"157 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thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-04"},"publish_date":"2023-08-04","publish_status":"0","recid":"2011134","relation_version_is_last":true,"title":["Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T09:53:48.230245+00:00"}